Human LRRTM3 Antibody

R&D Systems, part of Bio-Techne | Catalog # MAB4898

R&D Systems, part of Bio-Techne
Catalog #
Availability
Size / Price
Qty
MAB4898
MAB4898-SP
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2B Clone # 568318

View all LRRTM3 Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human LRRTM3
Glu31-Lys419
Accession # Q86VH5

Specificity

Detects human LRRTM3 in direct ELISAs. In direct ELISAs, 100% cross-reactivity with recombinant mouse (rm) LRRTM3 and no cross-reactivity with recombinant human LRRTM1, 2, or 4 is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Scientific Data Images for Human LRRTM3 Antibody

LRRTM3 antibody in Human Brain by Immunohistochemistry (IHC-P).

LRRTM3 in Human Brain.

LRRTM3 was detected in immersion fixed paraffin-embedded sections of human brain with Alzheimer's disease using Human LRRTM3 Monoclonal Antibody (Catalog # MAB4898) at 15 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Applications for Human LRRTM3 Antibody

Application
Recommended Usage

Immunohistochemistry

8-25 µg/mL
Sample: Immersion fixed paraffin-embedded sections of human brain with Alzheimer's disease

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Reconstitution

Sterile PBS to a final concentration of 0.5 mg/mL. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
Size / Price
Qty

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: LRRTM3

Human LRRTM3 (leucine-rich repeat transmembrane neuronal 3) is a 63 kDa (predicted) type I transmembrane glycoprotein that is one of four LRRTM family members within the LRR protein superfamily (1). The LRRTM3 cDNA encodes 581 amino acids (aa), including a 389 aa extracellular region that shares 98% aa identity with mouse and rat LRRTM3. Isoform 2 lacks cytoplasmic aa 514-581. LRRTMs in mouse show distinct expression patterns during formation of the central nervous system (CNS) and expression persists in adult brain. LRRTM3 promotes processing of amyloid precursor protein by BACE1, and may be mutated in late-onset Alzheimer’s disease.

Long Name

Leucine Rich Repeat Transmembrane Neuronal 3

Alternate Names

leucine rich repeat transmembrane neuronal 3, leucine-rich repeat transmembrane neuronal protein 3, MGC131810

Entrez Gene IDs

347731 (Human); 216028 (Mouse); 294380 (Rat)

Gene Symbol

LRRTM3

UniProt

Q86VH5 (Human)

Additional LRRTM3 Products

Product Documents for Human LRRTM3 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Download SDS

Product Specific Notices for Human LRRTM3 Antibody

For research use only

Privacy and Cookie Policy
Site Map
© Copyright 2024 Bio-Techne. All Rights Reserved.