Human mGluR3 Biotinylated Antibody
R&D Systems, part of Bio-Techne | Catalog # BAF4668
Key Product Details
Species Reactivity
Human
Applications
Western Blot
Label
Biotin
Antibody Source
Polyclonal Sheep IgG
Product Specifications
Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human mGluR3
Asp25-Ser507
Accession # Q14832
Asp25-Ser507
Accession # Q14832
Specificity
Detects human mGluR3 in Western blots. In Western blots, less than 5% cross-reactivity with recombinant human (rh) mGluR2 is observed and less than 1% cross-reactivity with rhmGluR1, rhmGluR4, rhmGluR5, rhmGluR7, and rhmGluR8 is observed.
Clonality
Polyclonal
Host
Sheep
Isotype
IgG
Applications for Human mGluR3 Biotinylated Antibody
Application
Recommended Usage
Western Blot
0.1 µg/mL
Sample: Recombinant Human mGluR3
Sample: Recombinant Human mGluR3
Please Note: Optimal dilutions of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Antigen Affinity-purified
Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: mGluR3
Metabotropic glutamate receptor 3 (mGluR3) is a 90-100 kDa, 7-transmembrane glycoprotein that belongs to group II of the C-family of G-protein coupled receptors. It is a presynaptic receptor expressed on both neurons and glia, whose activation reduces adenylate cyclase activity. Mature human mGluR3 is 857 amino acids in length and contains a 554 amino acid (aa) N-terminal extracellular domain (ECD) (aa 23-576). The ECD binds glutamate and forms homodimers. There is one alternative splice form that is soluble, 515 aa in length and shows a 96 aa substitution for aa 442-879. Over aa 25-507, human mGluR3 shares 97% aa sequence identity with mouse and rat mGluR3 and 67% aa sequence identity with hGluR2.
Long Name
Metabotropic Glutamate Receptor 3
Alternate Names
GPRC1C, GRM3
Gene Symbol
GRM3
UniProt
Additional mGluR3 Products
Product Documents for Human mGluR3 Biotinylated Antibody
Product Specific Notices for Human mGluR3 Biotinylated Antibody
For research use only
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