Human/Mouse Neurturin Biotinylated Antibody

R&D Systems, part of Bio-Techne | Catalog # BAF477

R&D Systems, part of Bio-Techne
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AF477
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Western Blot

Label

Biotin

Antibody Source

Polyclonal Goat IgG

View all Neurturin Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant mouse Neurturin
Pro96-Val195
Accession # P97463

Specificity

Detects human and mouse Neurturin in Western blots.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications for Human/Mouse Neurturin Biotinylated Antibody

Application
Recommended Usage

Western Blot

0.1 µg/mL
Sample: Recombinant Human Neurturin (Catalog # 1297-NE)
Recombinant Mouse Neurturin (Catalog # 477-MN)
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Reconstitution Buffer Available:
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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Neurturin

Neurturin (NTN) is a member of the GDNF family of ligands which also includes glial cell-derived neurotrophic factor (GDNF), persephin, and artemin. GDNF family proteins are distant members of the TGF-beta superfamily and contain a conserved seven cysteine motif found in the entire family. Human NTN encodes a 197 amino acid (aa) preproprotein with a 19 aa residue putative signal peptide and a 76 aa pro region. Proteolytic cleavage of the pro-protein occurs at an RXXR consensus sequence. The native protein is a disulfide-linked homodimer with a calculated monomeric mass of about 12.5 kDa. The amino acid sequence of human NTN shares 91% identity to mouse NTN. NTN also shares about 42% similarity with GDNF. The bioactivities of all GDNF family ligands are mediated through a receptor complex composed of a high affinity ligand binding component (GFR alpha1 - GFR alpha4) and a common signaling component, cRET (receptor tyrosine kinase). NTN prefers to bind GFR alpha2 but can also bind GFR alpha1. NTN can promote the survival of a variety of neurons including sympathetic, sensory, and central nervous system neurons. The wide expression of NTN in both neuronal and non-neuronal tissues suggests that NTN may regulate the development and maintenance of the central and peripheral nervous systems and other systems.

Alternate Names

NRTN, NTN

Entrez Gene IDs

4902 (Human); 18188 (Mouse)

Gene Symbol

NRTN

UniProt

P97463

Additional Neurturin Products

Product Documents for Human/Mouse Neurturin Biotinylated Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Human/Mouse Neurturin Biotinylated Antibody

For research use only

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