IA-2/PTPRN Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-00134

Novus Biologicals, part of Bio-Techne
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NBP1-00134
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Key Product Details

Species Reactivity

Validated:

Mouse

Predicted:

Human (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all IA-2/PTPRN Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-QGEGNIKKNRHPD corresponding to internal region according to NP_002837.1.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Theoretical MW

106 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for IA-2/PTPRN Antibody

Western Blot: IA-2/PTPRN Antibody [NBP1-00134]

Western Blot: IA-2/PTPRN Antibody [NBP1-00134]

Western Blot: IA-2/PTPRN Antibody [NBP1-00134] - Analysis of PTPRN in NIH 3T3 lysate (35ug protein in RIPA buffer) using this antibody at 0.5 ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for IA-2/PTPRN Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:16000

Western Blot

0.5 - 1.5 ug/ml
Application Notes
WB: Approx. 110 kDa band observed in NIH 3T3 lysates (calculated MW of 106 kDa band according to human NP_002837.1 and mouse NP_033011.2).
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: IA-2/PTPRN

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. [provided by RefSeq]

Long Name

Islet Cell Antigen 2/Protein Tyrosine Phosphatase Receptor-type N

Alternate Names

IA2, ICA512, PTPRN, R-PTP-N

Entrez Gene IDs

5798 (Human); 19275 (Mouse); 116660 (Rat)

Gene Symbol

PTPRN

UniProt

Q16849 (Human)

Additional IA-2/PTPRN Products

Product Documents for IA-2/PTPRN Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for IA-2/PTPRN Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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