ICEBERG Antibody

Novus Biologicals, part of Bio-Techne | Catalog # H00059082-B01P

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Mouse IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all ICEBERG Antibodies »

Product Specifications

Immunogen

ICEBERG (NP_067546.1, 1 a.a. - 90 a.a.) full-length human protein. MADQLLRKKRRIFIHSVGAGTINALLDCLLEDEVISQEDMNKVRDENDTVMDKARVLIDLVTGKGPKSCCKFIKHLCEEDPQLASKMGLH

Specificity

ICEBERG - ICEBERG caspase-1 inhibitor,

Clonality

Polyclonal

Host

Mouse

Isotype

IgG

Scientific Data Images for ICEBERG Antibody

Western Blot: ICEBERG Antibody [H00059082-B01P]

Western Blot: ICEBERG Antibody [H00059082-B01P]

Western Blot: ICEBERG Antibody [H00059082-B01P] - Analysis of CARD18 expression in transfected 293T cell line by CARD18 polyclonal antibody. Lane 1: ICEBERG transfected lysate(9.9 KDa). Lane 2: Non-transfected lysate.

Applications for ICEBERG Antibody

Application
Recommended Usage

Western Blot

1:500
Application Notes
Antibody reactive against recombinant protein with GST tag on ELISA and western blot and also on transfected lysate in western blot. GST tag alone is used as a negative control.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH 7.4)

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: ICEBERG

ICEBERG, also known as Caspase recruitment domain-containing protein 18, is a 90 amino acid protein that is 10 kDa, most often expressed in the heart and placenta, down-regulates the release of IL1B, and by interacting with caspase-1 and preventing its association with RIP2 inhibits the generation of IL-1-beta. This protein is being studied for its involvement in chronic lymphocytic leukemia. The ICEBERG protein has been linked to the NOD-like receptor signaling pathway where it interacts with CASP1, CARD8, CARD16, and CARD17.

Alternate Names

caspase recruitment domain family, member 18, Caspase-1 inhibitor Iceberg, ICEBERG caspase-1 inhibitor, ICEBERGcaspase recruitment domain-containing protein 18, pseudo-ICE, UNQ5804

Entrez Gene IDs

59082 (Human)

Gene Symbol

CARD18

UniProt

NP_067546.1 (Human)

Additional ICEBERG Products

Product Documents for ICEBERG Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for ICEBERG Antibody

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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