ICEBERG Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-48688

Novus Biologicals, part of Bio-Techne
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NBP2-48688
NBP2-48688-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all ICEBERG Antibodies »

Product Summary for ICEBERG Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: DTVMDKARVLIDLVTGKGPKSCCKFIKHLCEEDPQLASKMGLH

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for ICEBERG Antibody

Immunohistochemistry: ICEBERG Antibody [NBP2-48688]

Immunohistochemistry: ICEBERG Antibody [NBP2-48688]

Immunohistochemistry: ICEBERG Antibody [NBP2-48688] - Staining of human kidney shows strong cytoplasmic positivity in distal tubules.

Applications for ICEBERG Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ICEBERG

ICEBERG, also known as Caspase recruitment domain-containing protein 18, is a 90 amino acid protein that is 10 kDa, most often expressed in the heart and placenta, down-regulates the release of IL1B, and by interacting with caspase-1 and preventing its association with RIP2 inhibits the generation of IL-1-beta. This protein is being studied for its involvement in chronic lymphocytic leukemia. The ICEBERG protein has been linked to the NOD-like receptor signaling pathway where it interacts with CASP1, CARD8, CARD16, and CARD17.

Alternate Names

caspase recruitment domain family, member 18, Caspase-1 inhibitor Iceberg, ICEBERG caspase-1 inhibitor, ICEBERGcaspase recruitment domain-containing protein 18, pseudo-ICE, UNQ5804

Gene Symbol

CARD18

Additional ICEBERG Products

Product Documents for ICEBERG Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for ICEBERG Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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