IIGP1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-03970

Novus Biologicals, part of Bio-Techne
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NBP2-03970
NBP2-03970SS
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Key Product Details

Species Reactivity

Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1.0 mg/ml

View all IIGP1 Antibodies »

Product Specifications

Immunogen

A portion of amino acids 325-375 of mouse Iigp1 was used as the immunogen for this antibody.

Specificity

This antibody will detect both two isoforms of Iigp1 (413 amino acids and 346 amino acids).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for IIGP1 Antibody

Western Blot: IIGP1 Antibody [NBP2-03970]

Western Blot: IIGP1 Antibody [NBP2-03970]

Western Blot: IIGP1 Antibody [NBP2-03970] - Analysis of Iigp1 using Iigp1 polyclonal antibody. Mouse NIH 3T3 lysate in the absence (A) and presence (B) of immunizing peptide probed with Iigp1 antibody at 4 ug/ml. I goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.

Applications for IIGP1 Antibody

Application
Recommended Usage

Western Blot

3-5 ug/ml

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: IIGP1

Iigp1 (Interferon Inducible GTPase1) was first characterized as one of over 500 genes activated in response to Interferon g. Iigp1 is a 47kDa protein part of the GTPase1 family. Iigp1 demonstrates similar micro-molar nucleotide affinities and oligomerization-dependent hydrolytic activity with human GTPase hGBP1, 67-kDa GTPase (induced by type I and type II interferons) and with the antiviral Mx proteins (interferon type I-induced) (Boehm, 1998, Uthaiah, 2003). Binding affinity for Iigp1 is preferential for GDP rather than GTP. Induction of Iigp1 by poly I:C, a TLR3 ligand and interferon inducer, highlights the involvement of TLR3 signaling pathway. Iigp1 is under transcriptional control of IRF-1, a major pathway and indicator of the involvement of TRIF as the main adaptor molecule for TLR3 and Innate Immune signaling pathways in antiviral responses. Iigp1 functions as a mediator of bacterial resistance especially to intracellular pathogens including bacteria and viruses.

Alternate Names

2900074L10Rik, AI046432, AW111922, Ifgga1, Iigp, Iigp1, Irga6

Gene Symbol

Iigp1

UniProt

NP_068564.4 (Mouse)

Additional IIGP1 Products

Product Documents for IIGP1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for IIGP1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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