IL-1 RII Antibody (RM0014-7D7) - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NB110-85472

Novus Biologicals, part of Bio-Techne
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NB110-85472
NB110-85472-0.025mg
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Key Product Details

Species Reactivity

Mouse

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Rat IgG2 Clone # RM0014-7D7

Format

Azide and BSA Free

Concentration

LYOPH mg/ml

View all IL-1 RII Antibodies »

Product Specifications

Immunogen

Mouse IL-1 RII (extracellular domain)

Reactivity Notes

This antibody is reactive against Mouse.

Specificity

This recognizes extracellular domain of mouse IL1R-II protein.

Clonality

Monoclonal

Host

Rat

Isotype

IgG2

Scientific Data Images for IL-1 RII Antibody (RM0014-7D7) - Azide and BSA Free

Immunohistochemistry-Paraffin: IL-1 RII Antibody (RM0014-7D7) - Azide and BSA Free [NB110-85472]

Immunohistochemistry-Paraffin: IL-1 RII Antibody (RM0014-7D7) - Azide and BSA Free [NB110-85472]

Immunohistochemistry-Paraffin: IL-1 RII Antibody (RM0014-7D7) [NB110-85472] - IL1RII immunohistochemistry staining of paraffin sections of mouse Spleen and liver tissues from LPS exposed animals.

Applications for IL-1 RII Antibody (RM0014-7D7) - Azide and BSA Free

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

1:50-1:100

Western Blot

1:1000

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Reconstitution

Reconstitute with sterilized PBS to a final concentration of 0.5 mg/ml.

Formulation

Lyophilized from a 0.2 um filtered solution in PBS. 0.025 mg size is provided in liquid form, PBS

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: IL-1 RII

IL-1 receptor type II (IL1R-II) is a 65 kD member of the immunoglobulin superfamily also known as IL-1 receptor (IL-1R) type II. The IL-1R family is composed of three proteins: IL-1R type I, IL-1R type II, and the widely expressed IL-1R AcP. Both IL-1R type I and type II bind IL-1 alpha and IL-1 beta, although with differing affinities. The high affinity complex consists of IL-1R type I and IL-1R AcP, whereas IL-1 binds to IL-1R type II with low affinity. The IL-1 receptor antagonist (IL-1RA) can bind to both IL-1R type I and II. IL-1R type II is expressed at low levels on B cells, monocytes/macrophages, neutrophils, basal epithelia of the skin, and T cells. Binding of IL-1 to the high affinity IL-1 receptor mediates thymocyte and T cell activation, fibroblast proliferation, and induction of acute phase protein production. Binding of IL-1 to CDw121b appears to be dispensable for IL-1 signaling and may negatively regulate IL-1 responses acting as a "decoy" receptor.

Long Name

Interleukin 1 Receptor II

Alternate Names

CD121b, IL-1 R beta, IL-1RII, IL1R2, IL1RII

Entrez Gene IDs

16178 (Mouse)

Gene Symbol

IL1R2

Additional IL-1 RII Products

Product Documents for IL-1 RII Antibody (RM0014-7D7) - Azide and BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for IL-1 RII Antibody (RM0014-7D7) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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