IL-22R alpha 1 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-76724

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Cited:

Mouse

Applications

Validated:

ELISA, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Flow Cytometry

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all IL-22 R alpha 1 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a synthetic peptide corresponding to amino acids near the amino terminus of human IL-22 receptor precursor. The immunogen is located within the first 50 amino acids of IL-22 Receptor. Amino Acid Squence: QSSNFENILTWDSGPE

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Bovine (88%). Use in Mouse reported in scientific literature (PMID: 32127533). Use in Mouse reported in scientific literature (PMID:32127533).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

65 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for IL-22R alpha 1 Antibody - BSA Free

Western Blot: IL-22R alpha 1 AntibodyBSA Free [NBP1-76724]

Western Blot: IL-22R alpha 1 AntibodyBSA Free [NBP1-76724]

Western Blot: IL-22R alpha 1 Antibody [NBP1-76724] - Analysis of IL-22 receptor expression in human HepG2 cell lysate with IL-22 receptor antibody at (A) 0.5 and (B) 1 ug /ml.
Immunohistochemistry: IL-22R alpha 1 Antibody - BSA Free [NBP1-76724]

Immunohistochemistry: IL-22R alpha 1 Antibody - BSA Free [NBP1-76724]

Immunohistochemistry: IL-22R alpha 1 Antibody [NBP1-76724] - Staining of rat kidney tissue with antibody at 5 ug/mL.
Immunocytochemistry/ Immunofluorescence: IL-22R alpha 1 Antibody - BSA Free [NBP1-76724]

Immunocytochemistry/ Immunofluorescence: IL-22R alpha 1 Antibody - BSA Free [NBP1-76724]

Immunocytochemistry/Immunofluorescence: IL-22R alpha 1 Antibody [NBP1-76724] - Immunofluorescence:HepG2 cells with IL-22RA1 receptor antibody at 10 ug/ml.
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Applications for IL-22R alpha 1 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

10 ug/ml

Immunohistochemistry

5 ug/mL

Immunohistochemistry-Paraffin

5 ug/mL

Western Blot

0.5-1 ug/ml
Application Notes
Use in Flow Cytometry reported in scientific literature (PMID:32127533).

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: IL-22 R alpha 1

A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified. The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family. IL-22R forms a complex with IL-10 receptor beta chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-alpha 2 (IL-22RA2), was identified very recently. IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response.

Long Name

Interleukin 22 Receptor

Alternate Names

CRF2-9, IL-22Ra1, IL-TIF-R1, IL22R alpha 1, IL22RA1

Gene Symbol

IL22RA1

UniProt

AF286095 (Human)

Additional IL-22 R alpha 1 Products

Product Documents for IL-22R alpha 1 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for IL-22R alpha 1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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