IL-37/IL-1F7 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-27200

Novus Biologicals, part of Bio-Techne
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NBP2-27200SS
NBP2-27200
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Key Product Details

Species Reactivity

Human, Equine, Primate

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all IL-37/IL-1F7 Antibodies »

Product Specifications

Immunogen

A portion of amino acids 100-160 of human IL-37 were used as the immunogen.

Reactivity Notes

The amino acid sequence used as immunogen is 94% homologous in White-cheeked Gibbon, 89% homologous in Rhesus Macaque

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for IL-37/IL-1F7 Antibody

Western Blot: IL-37/IL-1F7 Antibody [NBP2-27200]

Western Blot: IL-37/IL-1F7 Antibody [NBP2-27200]

Western Blot: IL-37/IL-1F7 Antibody [NBP2-27200] - Lysate from human A431 cells in the 1) absence and 2) presence of immunizing peptide, and 3) ThP-1 probed with IL-37 antibody at 3 ug/ml.

Applications for IL-37/IL-1F7 Antibody

Application
Recommended Usage

Western Blot

2-4ug/ml

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

0.2 ml PBS and 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: IL-37/IL-1F7

IL-37, which is also known as IL-1F7, belongs to the Interleukin 1 cytokine family. It is reported to bind Interleukin 18 binding protein (IL18BP) which inhibits the IL18 protein functions. Functionally IL-37 forms a complex with IL-18 receptor beta subunit and thus inhibits the activity of IL-18. It is also reported that IL-37 acts as fundamental inhibitor of innate immunity. Experimental studies show that expression of IL-37 in macrophages or epithelial cells almost completely suppressed production of pro-inflammatory cytokines, whereas the abundance of these cytokines increased with silencing of endogenous IL-37 in human blood cells.

Long Name

Interleukin 37

Alternate Names

FIL1 zeta, IL-1F7, IL37

Gene Symbol

IL37

UniProt

Q9NZH6 (Human)

Additional IL-37/IL-1F7 Products

Product Documents for IL-37/IL-1F7 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for IL-37/IL-1F7 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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