IL-3R beta Antibody (130705) [Allophycocyanin/Cy7]
Novus Biologicals, part of Bio-Techne | Catalog # FAB5492APCCY7
Key Product Details
Species Reactivity
Applications
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Antibody Source
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Product Specifications
Immunogen
His23-Trp440
Accession # P26954
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Isotype
Applications for IL-3R beta Antibody (130705) [Allophycocyanin/Cy7]
Flow Cytometry
Formulation, Preparation, and Storage
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Stability & Storage
Background: IL-3R beta
Interleukin 3 (IL-3) is a pleiotropic cytokine that can stimulate proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. IL-3 exerts its activity through binding to a specific cell surface receptor known as IL-3 R. IL-3 R is a heterodimeric structure composed of a 70 kDa IL-3 R alpha subunit (CD123 or beta common) and a 120-140 kDa IL-3 R beta subunit (CD131). CD131 also associates with the receptor for Erythropoietin, forming a tissue-protective hetero-receptor complex.
IL-3 R alpha binds IL-3 with relatively low affinity. In the presence of IL-3 R beta, however, IL-3 R alpha has a much higher affinity for IL-3. It is not clear how signal transduction occurs following IL-3 binding. The IL-3 R alpha chain has a very short intracellular domain while the IL-3 R beta chain has a very large cytoplasmic domain. Recent studies suggest that formation of IL-3 R beta-beta homodimers initiates signaling events. The IL-3 R beta chain is also shared by the receptors for IL-5 and GM-CSF. Cells known to express IL-3 receptors include hematopoietic progenitors, epithelial cells, double negative T cells, mast cells, basophils and blood monocytes.
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Additional IL-3R beta Products
Product Documents for IL-3R beta Antibody (130705) [Allophycocyanin/Cy7]
Product Specific Notices for IL-3R beta Antibody (130705) [Allophycocyanin/Cy7]
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.