INCA Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-46144

Novus Biologicals, part of Bio-Techne
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NBP1-46144
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Key Product Details

Species Reactivity

Human

Applications

Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all INCA Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-NHLTTQDSQIVLPS corresponding to C-Terminus according to NP_001007233.1.

Epitope

C-Terminus

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for INCA Antibody

Western Blot: INCA Antibody [NBP1-46144]

Western Blot: INCA Antibody [NBP1-46144]

Western Blot: INCA Antibody [NBP1-46144] - NBP1-46144 (0.5ug/ml) staining of Human Kidney lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for INCA Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:8000

Western Blot

0.5 - 1.5 ug/ml
Application Notes
WB: Approx. 15 kDa band double band observed in human kidney and lung lysates (calculated MW of 11.9 kDa band according to NP_001007233.1).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: INCA

INCA, also known as CAR17 or Caspase recruitment domain-containing protein 17, is a 110 amino acid protein that is 12 kDa; cytoplasm located; regulates procaspase-1/CASP1 activation involved in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation; and acts as an inhibitor of the release of IL1B in response to LPS in monocytes. Current research is being pursued on this protein involvement in several diseases and disorders including cancer, familial mediterranean fever, shigellosis, cowpox, neurodegenerative disease, vascular disease, mevalonic aciduria, tularemia, dermatitis, lung disease, legionnaires' disease, and arthritis. This protein has been linked to the proteolysis and regulation of apoptotic process pathways where it interacts with CASP1, CARD16, and CARD18 proteins.

Alternate Names

caspase recruitment domain family, member 17, caspase recruitment domain-containing protein 17, Caspase-1 inhibitor INCA, INCAInhibitory CARD, inhibitory caspase recruitment domain (CARD) protein, Inhibitory caspase recruitment domain protein

Entrez Gene IDs

440068 (Human)

Gene Symbol

CARD17

UniProt

NP_001007233.1 (Human)

Additional INCA Products

Product Documents for INCA Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for INCA Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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