INSRR/IR-related receptor Antibody (6E6)

Novus Biologicals, part of Bio-Techne | Catalog # H00003645-M01

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Sandwich ELISA, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # 6E6

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all INSRR Antibodies »

Product Specifications

Immunogen

INSRR (NP_055030, 651 a.a. ~ 760 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. LYLNDYCHRGLRLPTSNNDPRFDGEDGDPEAEMESDCCPCQHPPPGQVLPPLEAQEASFQKKFENFLHNAITIPISPWKVTSINKSPQRDSGRHRRAAGPLRLGGNSSDF

Localization

Cell Membrane; single-pass type I membrane protein.

Specificity

INSRR - insulin receptor-related receptor

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Description

Quality control test: Antibody Reactive Against Recombinant Protein.

Scientific Data Images for INSRR/IR-related receptor Antibody (6E6)

Western Blot: INSRR/IR-related receptor Antibody (6E6) [H00003645-M01]

Western Blot: INSRR/IR-related receptor Antibody (6E6) [H00003645-M01]

Western Blot: INSRR/IR-related receptor Antibody (6E6) [H00003645-M01] - INSRR monoclonal antibody (M01), clone 6E6 Analysis of INSRR expression in HeLa.
Immunohistochemistry-Paraffin: INSRR/IR-related receptor Antibody (6E6) [H00003645-M01]

Immunohistochemistry-Paraffin: INSRR/IR-related receptor Antibody (6E6) [H00003645-M01]

Immunohistochemistry-Paraffin: INSRR/IR-related receptor Antibody (6E6) [H00003645-M01] - Analysis of monoclonal antibody to INSRR on formalin-fixed paraffin-embedded human esophagus. Antibody concentration 1 ug/ml.
Sandwich ELISA: INSRR/IR-related receptor Antibody (6E6) [H00003645-M01] - Detection limit for recombinant GST tagged INSRR is approximately 0.03ng/ml as a capture antibody.

Applications for INSRR/IR-related receptor Antibody (6E6)

Application
Recommended Usage

Western Blot

1:500
Application Notes
Antibody reactivity against cell lysate and recombinant protein for WB. It has also been used for IHC-P and ELISA.

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: INSRR

The insulin receptor related receptor (IRR) is a heterotetrameric transmembrane receptor composed of two alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. Member of the insulin RTK family, IRR shares high homology with the insulin (IR) and the insulin-like growth factor-1 receptor (IGF-1R), but doesn't bind any of IR and IGF-1R known ligands (1-2). In contrast to the widespread patterns of expression to IR and IGF-1R, IRR demonstrates a very restricted cellular distribution in a subset of tissues of neuronal origin and its biological functions are still unknown (3).

Long Name

Insulin Receptor-related Receptor

Alternate Names

IRR

Entrez Gene IDs

3645 (Human)

Gene Symbol

INSRR

OMIM

147671 (Human)

UniProt

NP_055030

Additional INSRR Products

Product Documents for INSRR/IR-related receptor Antibody (6E6)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for INSRR/IR-related receptor Antibody (6E6)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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