Integrin beta 3/CD61 Antibody (S02-5I9)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-19667

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-19667-100ul
NBP3-19667-50ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S02-5I9

Concentration

0.3 mg/ml

View all Integrin beta 3/CD61 Antibodies »

Product Summary for Integrin beta 3/CD61 Antibody (S02-5I9)

Immunogen

Recombinant protein of human Integrin beta 3/CD61 (Uniprot # P05106)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

100 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Integrin beta 3/CD61 Antibody (S02-5I9)

Western Blot: Integrin beta 3/CD61 Antibody (S02-5I9) [NBP3-19667]

Western Blot: Integrin beta 3/CD61 Antibody (S02-5I9) [NBP3-19667]

Western Blot: Integrin beta 3/CD61 Antibody (S02-5I9) [NBP3-19667] - Western blot detection of Integrin beta 3/CD61 in Hela cell lysates using NBP3-19667 (1:1000 diluted). Predicted band size: 87kDa. Observed band size: 100kDa.

Applications for Integrin beta 3/CD61 Antibody (S02-5I9)

Application
Recommended Usage

Western Blot

1/1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Integrin beta 3/CD61

Platelet membrane glycoprotein Integrin beta-3 (GP IIIa) forms a Ca2+-dependent heterodimer complex with GP IIb. The GP IIb-IIIa complex constitutes the fibrinogen and fibronectin receptor on stimulated platelets. A biochemically and immunologically similar membrane glycoprotein complex is present on endothelial cells. Homology suggests that GP IIIa is a member of a family of cell-surface adhesion receptors. (1) Data provide further support for the key role of the cytoplasmic domain of the beta3 integrin in cell adhesion and suggest a potential role for the beta3C integrin subunit in modulating cell-matrix interactions (2). It has been demonstrated that the beta 3 subunit of alpha IIb beta 3 was phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Data suggest that tyrosine phosphorylation of an integrin beta subunit may be important in initiating outside-in signaling cascades by inducing association of signaling components directly with the integrin (3). be important in initiating outside-in signaling cascades by inducing association of signaling components directly with the integrin (3).

Alternate Names

CD61, GP3A, GPIIIA, INGRB3, ITGB3

Gene Symbol

ITGB3

Additional Integrin beta 3/CD61 Products

Product Documents for Integrin beta 3/CD61 Antibody (S02-5I9)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Integrin beta 3/CD61 Antibody (S02-5I9)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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