Key Product Details

Validated by

Independent Antibodies, Biological Validation

Species Reactivity

Human, Mouse

Applications

Immunohistochemistry, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1.0 mg/ml

View all integrin beta 4 binding protein Antibodies »

Product Specifications

Immunogen

The immunogen for this product maps to a region between residue 150 and 200 of human Eukaryotic Translation Initiation Factor 6 using the numbering given in entry NP_852133.1 (GeneID 3692).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for integrin beta 4 binding protein Antibody

Western Blot: integrin beta 4 binding protein Antibody [NBP1-52641]

Western Blot: integrin beta 4 binding protein Antibody [NBP1-52641]

Western Blot: integrin beta 4 binding protein Antibody [NBP1-52641] - Affinity purified rabbit anti-eIF6 antibody used for WB at 0.1 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 6 mcg/mg lysate. eIF6 was also immunoprecipitated by rabbit anti-eIF6 antibody NBP1-52640, which recognizes an upstream epitope.
Immunohistochemistry: integrin beta 4 binding protein Antibody [NBP1-52641]

Immunohistochemistry: integrin beta 4 binding protein Antibody [NBP1-52641]

Immunohistochemistry: integrin beta 4 binding protein Antibody [NBP1-52641] - Samples: FFPE serial sections of mouse renal cell carcinoma. Antibody: Affinity purified rabbit anti- eIF6 used at a dilution of 1:1,000 (1ug/ml). Detection: DAB. Counterstain: Hematoxylin (blue).
Immunohistochemistry: integrin beta 4 binding protein Antibody [NBP1-52641]

Immunohistochemistry: integrin beta 4 binding protein Antibody [NBP1-52641]

Immunohistochemistry: integrin beta 4 binding protein Antibody [NBP1-52641] - Samples: FFPE serial sections of human ovarian carcinoma. Antibody: Affinity purified rabbit anti- eIF6 used at a dilution of 1:1,000 (1ug/ml). Detection: DAB. Counterstain: Hematoxylin (blue).

Applications for integrin beta 4 binding protein Antibody

Application
Recommended Usage

Immunoprecipitation

2-5 mcg/mg

Western Blot

1:2000-1:10000

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris-Citrate/Phosphate (pH 7.0 - 8.0)

Preservative

0.09% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: integrin beta 4 binding protein

Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple transcript variants encoding two different isoforms have been found for this gene.

Alternate Names

b(2)gcn, B(2)GCN homolog, B4 integrin interactor, CAB, EIF3Ap27(BBP), eIF-6, eukaryotic translation initiation factor 3A, eukaryotic translation initiation factor 6, ITGB4BPintegrin beta 4 binding protein, p27 beta-4 integrin-binding protein, p27BBP

Gene Symbol

EIF6

Additional integrin beta 4 binding protein Products

Product Documents for integrin beta 4 binding protein Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for integrin beta 4 binding protein Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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