integrin beta 4 binding protein Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-16975

Novus Biologicals, part of Bio-Techne
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NBP2-16975
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Key Product Details

Validated by

Knockout/Knockdown

Species Reactivity

Validated:

Human, Mouse, Rat

Predicted:

Bovine (97%), Chicken (94%), Mouse (99%), Porcine (98%), Rat (99%), Sheep (99%), Xenopus (91%), Zebrafish (92%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all integrin beta 4 binding protein Antibodies »

Product Specifications

Immunogen

Recombinant protein encompassing a sequence within the center region of human integrin beta 4 binding protein. The exact sequence is proprietary.

Reactivity Notes

Drosophila (82%), , Xenopus laevis (91%).

Localization

Cytoplasm; Nucleus

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

27 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for integrin beta 4 binding protein Antibody

Western Blot: integrin beta 4 binding protein Antibody [NBP2-16975]

Western Blot: integrin beta 4 binding protein Antibody [NBP2-16975]

Western Blot: integrin beta 4 binding protein Antibody [NBP2-16975] - Various whole cell extracts (30 ug) were separated by 12% SDS-PAGE, and the membrane was blotted with EIF6 antibody [N1C3-2] diluted at 1:5000. The HRP-conjugated anti-rabbit IgG antibody (NBP2-19301) was used to detect the primary antibody.
Immunohistochemistry-Paraffin: integrin beta 4 binding protein Antibody [NBP2-16975]

Immunohistochemistry-Paraffin: integrin beta 4 binding protein Antibody [NBP2-16975]

Immunohistochemistry-Paraffin: integrin beta 4 binding protein Antibody [NBP2-16975] - Human colon. EIF6 antibody [N1C3-2] diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
integrin beta 4 binding protein Antibody

Western Blot: integrin beta 4 binding protein Antibody [NBP2-16975] -

Western Blot: integrin beta 4 binding protein Antibody [NBP2-16975] - Various whole cell extracts (50 ug) were separated by 12% SDS-PAGE, and the membrane was blotted with integrin beta 4 binding protein antibody [N1C3-2] (NBP2-16975) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
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Applications for integrin beta 4 binding protein Antibody

Application
Recommended Usage

Immunohistochemistry

1:100-1:1000

Immunohistochemistry-Paraffin

1:100-1:1000

Western Blot

1:1000-1:10000

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

PBS (pH 7), 20% Glycerol

Preservative

0.025% Proclin 300

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: integrin beta 4 binding protein

Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq]

Alternate Names

b(2)gcn, B(2)GCN homolog, B4 integrin interactor, CAB, EIF3Ap27(BBP), eIF-6, eukaryotic translation initiation factor 3A, eukaryotic translation initiation factor 6, ITGB4BPintegrin beta 4 binding protein, p27 beta-4 integrin-binding protein, p27BBP

Gene Symbol

EIF6

UniProt

P56537 (Human)

Additional integrin beta 4 binding protein Products

Product Documents for integrin beta 4 binding protein Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for integrin beta 4 binding protein Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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