Integrin beta 7 Antibody (2G18) [PE]

Novus Biologicals, part of Bio-Techne | Catalog # NB110-94147PE

Novus Biologicals, part of Bio-Techne
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NB110-94147PE
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Key Product Details

Species Reactivity

Mouse

Applications

Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunoprecipitation

Label

PE (Excitation = 488 nm, Emission = 575 nm)

Antibody Source

Monoclonal Rat IgG2 Clone # 2G18

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Integrin beta 7 Antibodies »

Product Specifications

Immunogen

Cell lysates of mouse lymphocytes

Clonality

Monoclonal

Host

Rat

Isotype

IgG2

Description

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Applications for Integrin beta 7 Antibody (2G18) [PE]

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Integrin beta 7

Integrin beta7 is a 130 kD glycoprotein, also known as integin betap. It is a member of the Ig superfamily. In association with integrin alpha4 or alphaE chain, beta7 forms alpha4/ beta7 or alphaE/ beta7 heterodimer. alpha4/ beta7 (CD49d/ beta7, LPAM-1) is expressed on majority of peripheral lymphocytes, small subsets of thymocytes and bone marrow progenitors. LPAM-1 binds to several ligands, VCAM-1, MAdCAM-1 and fibronectin, and is involved in lymphocyte adhesion, some hematopoietic progenitor cells migration. alphaE/ beta7 (CD103/ beta7, alphaIEL/ beta7) is expressed on intestinal intraepithelial lymphocytes (IEL), dendritic epidermal T cells, T regulatory cells, a subset of CD8+ T cells in lymph nodes and lamina propria. CD103/ beta7 complex is thought to play a role in lymphocyte retention via interaction with its lignd E-Cadherin. The Fib504 antibody has been reported to react with mouse and human beta7 integrin and to block beta7 integrin-mediated cell adhesion in in vitro and in vivo studies.

Alternate Names

ITGB7

Gene Symbol

ITGB7

Additional Integrin beta 7 Products

Product Documents for Integrin beta 7 Antibody (2G18) [PE]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Integrin beta 7 Antibody (2G18) [PE]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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