INTS6 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-85302

Novus Biologicals, part of Bio-Techne
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NBP1-85302
NBP1-85302-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all INTS6 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: VVNNHIGGKGPPAPTTQAQPDLIKPLPLHKISETTNDSIIHDVVENHVADQLSSDITPNAMDTEFSASSPASLLERPTNHMEALGHDHLGTNDLTVGGFLENHEEPRDKEQCAEENIPASSLNKGKKLMHCRSHEEVNTELKAQ

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (85%), Rat (83%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for INTS6 Antibody

Western Blot: INTS6 Antibody [NBP1-85302]

Western Blot: INTS6 Antibody [NBP1-85302]

Western Blot: INTS6 Antibody [NBP1-85302] - Lane 1: Marker [kDa] 219, 112, 85, 49, 32, 25, 18. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp. Lane 4: Human cell line A-431
Immunocytochemistry/ Immunofluorescence: INTS6 Antibody [NBP1-85302]

Immunocytochemistry/ Immunofluorescence: INTS6 Antibody [NBP1-85302]

Immunocytochemistry/Immunofluorescence: INTS6 Antibody [NBP1-85302] - Staining of human cell line U-251 MG shows localization to nucleoplasm. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: INTS6 Antibody [NBP1-85302]

Immunohistochemistry-Paraffin: INTS6 Antibody [NBP1-85302]

Immunohistochemistry-Paraffin: INTS6 Antibody [NBP1-85302] - Staining of human testis shows moderate nuclear positivity in cells in seminiferous ducts.
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Applications for INTS6 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: INTS6

The tumor suppressor gene DICE1 is located within a previously reported critical region of loss of heterozygosity on chromosome 13q14.3. Expression of the remaining DICE1 allele is down-regulated in non-small cell lung carcinomas. In IGF-IR transformed Balb/c 3T3, DICE1 substantially suppressed growth in soft agar. These results demonstrate that DICE1 has a growth-suppressing activity and interferes with anchorage-independent growth of IGF-IR transformed tumor cells dependent upon IGF-I signaling.

Alternate Names

DBI1, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26, DICE1DBI-1DDX26ADDX26DEAD box protein, DKFZp434B105, HDB, Int6, integrator complex subunit 6, Notchl2, Protein DDX26, Protein deleted in cancer 1, RNA helicase HDB

Gene Symbol

INTS6

Additional INTS6 Products

Product Documents for INTS6 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for INTS6 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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