IRS2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-68242

Novus Biologicals, part of Bio-Techne
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NB100-68242
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Key Product Details

Validated by

Independent Antibodies

Species Reactivity

Validated:

Human

Applications

Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.2 mg/ml

View all IRS2 Antibodies »

Product Summary for IRS2 Antibody

Immunogen

The immunogen recognized by this antibody maps to a region between residue 600 and 650 of human insulin receptor substrate 2 using the numbering given in entry NP_003740.2 (GeneID 8660).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for IRS2 Antibody

Western Blot: IRS2 Antibody [NB100-68242]

Western Blot: IRS2 Antibody [NB100-68242]

Western Blot: IRS2 Antibody [NB100-68242] - Detection of Human IRS2 NB100-68242. IRS2 was also immunoprecipitated by rabbit anti-IRS2 antibodies NB100-68243 and NB100-68244.

Applications for IRS2 Antibody

Application
Recommended Usage

Immunoprecipitation

2-5 ug/mg lysate

Western Blot

1:2000-1:10000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

TBS and 0.1% BSA

Preservative

0.09% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: IRS2

IRS2 is a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1 (IGF1), and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. IRS2 is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. IRS2-deficient mice display all the characteristics of type 2 diabetes, suggesting that dysfunction of the IRS2 gene may contribute to the pathogenesis of human type 2 diabetes. Recent work has demonstrated a critical role for IRS2 in the maintenance of peripheral insulin sensitivity, central leptin sensitivity, proper beta cell development in the islets of Langerhans and expansion of functional beta-cell mass in vivo.

Long Name

Insulin Receptor Substrate 2

Alternate Names

insulin receptor substrate 2, IRS-2

Entrez Gene IDs

8660 (Human)

Gene Symbol

IRS2

UniProt

Q9Y4H2 (Human)

Additional IRS2 Products

Product Documents for IRS2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for IRS2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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