IRS2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-68242

Novus Biologicals, part of Bio-Techne
Catalog #
Availability
Size / Price
Qty
NB100-68242
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Validated by

Independent Antibodies

Species Reactivity

Human

Applications

Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.2 mg/ml

View all IRS2 Antibodies »

Product Specifications

Immunogen

The immunogen recognized by this antibody maps to a region between residue 600 and 650 of human insulin receptor substrate 2 using the numbering given in entry NP_003740.2 (GeneID 8660).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for IRS2 Antibody

Western Blot: IRS2 Antibody [NB100-68242]

Western Blot: IRS2 Antibody [NB100-68242]

Western Blot: IRS2 Antibody [NB100-68242] - Detection of Human IRS2 NB100-68242. IRS2 was also immunoprecipitated by rabbit anti-IRS2 antibodies NB100-68243 and NB100-68244.

Applications for IRS2 Antibody

Application
Recommended Usage

Immunoprecipitation

2-5 ug/mg lysate

Western Blot

1:2000-1:10000

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

TBS and 0.1% BSA

Preservative

0.09% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: IRS2

IRS2 is a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1 (IGF1), and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. IRS2 is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. IRS2-deficient mice display all the characteristics of type 2 diabetes, suggesting that dysfunction of the IRS2 gene may contribute to the pathogenesis of human type 2 diabetes. Recent work has demonstrated a critical role for IRS2 in the maintenance of peripheral insulin sensitivity, central leptin sensitivity, proper beta cell development in the islets of Langerhans and expansion of functional beta-cell mass in vivo.

Long Name

Insulin Receptor Substrate 2

Alternate Names

insulin receptor substrate 2, IRS-2

Entrez Gene IDs

8660 (Human)

Gene Symbol

IRS2

UniProt

Q9Y4H2 (Human)

Additional IRS2 Products

Product Documents for IRS2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for IRS2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Privacy and Cookie Policy
Site Map
© Copyright 2024 Bio-Techne. All Rights Reserved.