ITCH/AIP4 Antibody (1B8)

Novus Biologicals, part of Bio-Techne | Catalog # H00083737-M06

Novus Biologicals, part of Bio-Techne
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H00083737-M06
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Sandwich ELISA

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2b Kappa Clone # 1B8

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all ITCH/AIP4 Antibodies »

Product Specifications

Immunogen

ITCH (NP_113671, 92 a.a. ~ 190 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. DVLLGTAALDIYETLKSNNMKLEEVVVTLQLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGSDDPEDAGAGE

Specificity

ITCH - itchy homolog E3 ubiquitin protein ligase (mouse) (1B8)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2b Kappa

Scientific Data Images for ITCH/AIP4 Antibody (1B8)

Immunocytochemistry/ Immunofluorescence: ITCH/AIP4 Antibody (1B8) [H00083737-M06]

Immunocytochemistry/ Immunofluorescence: ITCH/AIP4 Antibody (1B8) [H00083737-M06]

Immunocytochemistry/Immunofluorescence: ITCH/AIP4 Antibody (1B8) [H00083737-M06] - Analysis of monoclonal antibody to ITCH on HeLa cell. Antibody concentration 10 ug/ml
Sandwich ELISA: ITCH/AIP4 Antibody (1B8) [H00083737-M06] - Detection limit for recombinant GST tagged ITCH is 1 ng/ml as a capture antibody.

Applications for ITCH/AIP4 Antibody (1B8)

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Sandwich ELISA

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
This product is useful for ELISA.

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: ITCH/AIP4

Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells. [provided by RefSeq]

Long Name

Itchy E3 Ubiquitin Protein Ligase

Alternate Names

AIF4, AIP4, NAPP1

Entrez Gene IDs

83737 (Human)

Gene Symbol

ITCH

UniProt

NP_113671 (Human)

Additional ITCH/AIP4 Products

Product Documents for ITCH/AIP4 Antibody (1B8)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for ITCH/AIP4 Antibody (1B8)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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