ITM2C Antibody

Novus Biologicals, part of Bio-Techne | Catalog # H00081618-B01P

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Mouse IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all ITM2C Antibodies »

Product Specifications

Immunogen

ITM2C (AAH25742, 1 a.a. - 230 a.a.) full-length human protein. MVKISFQPAVAGIKGDKADKASASAPAPASATEILLTPAREEQPPQHRSKRGSSVGGVCYLSMGMVVLLMGLVFASVYIYRYFFLAQLARDNFFRCGVLYEDSLSSQVRTQMELEEDVKIYLDENYERINVPVPQFGGGDPADIIHDFQRRGTYLPQTYIIQEEMVVTEHVSDKEALGSFIYHLCNGKDTYRLRRRATRRRINKRGAKNCNAIRHFENTFVVETLICGVV

Specificity

ITM2C - integral membrane protein 2C,

Clonality

Polyclonal

Host

Mouse

Isotype

IgG

Scientific Data Images for ITM2C Antibody

Western Blot: ITM2C Antibody [H00081618-B01P]

Western Blot: ITM2C Antibody [H00081618-B01P]

Western Blot: ITM2C Antibody [H00081618-B01P] - Analysis of ITM2C expression in transfected 293T cell line by ITM2C polyclonal antibody. Lane 1: ITM2C transfected lysate(25.41 KDa). Lane 2: Non-transfected lysate.

Applications for ITM2C Antibody

Application
Recommended Usage

Western Blot

1:500
Application Notes
Antibody reactive against Recombinant Protein with GST tag on ELISA and Western Blot and also on transfected lysate in western blot. GST tag alone is used as a negative control.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

PBS (pH 7.4)

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: ITM2C

ITM2C also known as Integral membrane protein 2C, has 3 isoforms, an isoform 1that is 267 amino acid and 30 kDa, an isoform 2 that is 220 amino acid and 25 kDa, and an isoform 3 that is 230 amino acid and 26 kDa; most commonly found in the brain tissue; acts as negative regulator of beta amyloid peptide production, may inhibit the processing of APP by blocking its access to alpha- and beta-secretase, appears to be a poor gamma-secretase cleavage inhibitor, and may play a role in TNF-induced cell death and neuronal differentiation. Studies are being performed on the relationship of this protein to anemia of prematurity, cerebritis, anemia, dementia, influenza, gastric cancer, and neuronitis. The protein has been shown to interact with BACE1, APP, STMN2, STT3A, RNF7, and FURIN proteins in negative regulation of neuron projection development, induction of programmed cell death, and neuron differentiation pathways.

Long Name

Integral Membrane Protein 2C

Alternate Names

BRI3, BRICD2C, Cerebral protein 14

Entrez Gene IDs

81618 (Human)

Gene Symbol

ITM2C

UniProt

AAH25742 (Human)

Additional ITM2C Products

Product Documents for ITM2C Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for ITM2C Antibody

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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