Jak3 Antibody (1C7)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-15196

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-15196
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunohistochemistry

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 1C7

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Jak3 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human JAK3. UniProt ID (P52333).

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Jak3 Antibody (1C7)

Immunohistochemistry: Jak3 Antibody (1C7) [NBP3-15196]

Immunohistochemistry: Jak3 Antibody (1C7) [NBP3-15196]

Immunohistochemistry: Jak3 Antibody (1C7) [NBP3-15196] - IHC image of JAK3 antibody diluted at 1:100 and staining in paraffin-embedded human lung cancer. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30 minutes at RT. Then primary antibody (1% BSA) was incubated at 4C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Applications for Jak3 Antibody (1C7)

Application
Recommended Usage

Immunohistochemistry

1:50-1:200

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 150mM NaCl, and 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20 to -80C. Avoid freeze-thaw cycles.

Background: Jak3

Jak3 (Janus Kinase 3) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK3. JAK3 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system, stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.

Alternate Names

JAKL, LJAK

Gene Symbol

JAK3

Additional Jak3 Products

Product Documents for Jak3 Antibody (1C7)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Jak3 Antibody (1C7)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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