JMJD6/PSR Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-71693

Novus Biologicals, part of Bio-Techne
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NBP1-71693
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (98%), Mouse (98%), Rat (98%), Xenopus (91%), Zebrafish (91%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.2 mg/ml

View all JMJD6/PSR Antibodies »

Product Summary for JMJD6/PSR Antibody

Immunogen

A genomic peptide made to an internal region of the human JMJD6 protein (within residues 150-350). [Swiss-Prot Q6NYC1]

Reactivity Notes

Immunogen has 98% identity with mouse, rat and bovine. Immunogen has 91% identity to Xenopus and Zebrafish.

Localization

Nucleus.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for JMJD6/PSR Antibody

Western Blot: JMJD6/PSR Antibody [NBP1-71693]

Western Blot: JMJD6/PSR Antibody [NBP1-71693]

Western Blot: JMJD6/PSR Antibody [NBP1-71693] - Analysis of JMJD6 in A431 cell lysate.
Immunocytochemistry/ Immunofluorescence: JMJD6/PSR Antibody [NBP1-71693]

Immunocytochemistry/ Immunofluorescence: JMJD6/PSR Antibody [NBP1-71693]

Immunocytochemistry/Immunofluorescence: JMJD6/PSR Antibody [NBP1-71693] - JMJD6 antibody was tested at 10 ug/ml in A431 cells with FITC (green). Nuclei (Blue) were counterstained with Dapi (blue).

Applications for JMJD6/PSR Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Western Blot

1:2000
Application Notes
This JMJD6 antibody is useful for ICC and Western Blot, where a band is seen ~45 kDa.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Reviewed Applications

Read 1 review rated 5 using NBP1-71693 in the following applications:

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS, 0.1% BSA, and 50% Glycerol

Preservative

0.05% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: JMJD6/PSR

Jumonji domain containing 6 is a histone demethylating enzyme, which is active on arginine residues, but not lysines. Its activity destabilizes heterochromatin structures and activates gene expressions in euchromatin. In endothelial cells, the activity of JMJD6 is necessary for angiogenesis. If JMJD6 expression is reduced, the VEGF-receptor (Flt-1) is incorrectly spliced, leading to increased soluble Flt-1 which binds VEGF and PlGF and inhibits angiogenesis. JMJD6 also hydroxylates RNA splicing factors, and is important in embryonic differentiation. It most likely interacts specifically with single-stranded RNA, which may contribute to its early differentiation importance.

Long Name

Jumonji Domain Containing 6/Phosphatidylserine Receptor

Alternate Names

PSR, PTDSR

Entrez Gene IDs

23210 (Human)

Gene Symbol

JMJD6

UniProt

Q6NYC1 (Human)

Additional JMJD6/PSR Products

Product Documents for JMJD6/PSR Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for JMJD6/PSR Antibody

Manufactured by Genomic Antibody Technology™. GAT FAQs

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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