Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all JPH1 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human JPH1. The immunogen is located within amino acids 470 - 520 of JPH1. Amino Acid Squence: SGARLNQDKRSVADE

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Rabbit (87%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for JPH1 Antibody - BSA Free

Western Blot: JPH1 AntibodyBSA Free [NBP1-77338]

Western Blot: JPH1 AntibodyBSA Free [NBP1-77338]

Western Blot: JPH1 Antibody [NBP1-77338] - 293 cell lysate with JPH1 antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry-Paraffin: JPH1 Antibody - BSA Free [NBP1-77338]

Immunohistochemistry-Paraffin: JPH1 Antibody - BSA Free [NBP1-77338]

Immunohistochemistry-Paraffin: JPH1 Antibody [NBP1-77338] - Mouse skeletal muscle tissue with JPH1 antibody at 2.5 ug/ml.
JPH1 Antibody - BSA Free

Immunohistochemistry: JPH1 Antibody - BSA Free [NBP1-77338] -

Immunohistochemistry: JPH1 Antibody - BSA Free [NBP1-77338] - Immunohistochemistry of JPH1 in mouse skeletal muscle tissue with JPH1 antibody at 2.5 u/mL.
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Applications for JPH1 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunohistochemistry

2.5 ug/ml

Immunohistochemistry-Paraffin

2.5 ug/ml

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: JPH1

Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Junctophilins (JPs) are important components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. Four JPs have been identified as tissue-specific subtypes derived from different genes: JPH1 is expressed in skeletal muscle, JPH2 is detected throughout all muscle cell types, and JPH3 and JPH4 are predominantly expressed in the brain and contribute to the subsurface cistern formation in neurons. JPH1 is essential for stabilizing the T-tubule and SR membranes to form junctions and provide an environment for the assembly of receptors such as the ryanodine receptor type 1 (RyR1).

Alternate Names

DKFZp762L0313, JP-1junctophilin type1, JP1junctophilin-1, junctophilin 1, Junctophilin type 1, mitsugumin72

Gene Symbol

JPH1

UniProt

AAI39833 (Human)

Additional JPH1 Products

Product Documents for JPH1 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for JPH1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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