KAT1 Antibody (S04-3G4)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-19521

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-19521-100ul
NBP3-19521-50ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S04-3G4

Concentration

0.3 mg/ml

View all KAT1 Antibodies »

Product Summary for KAT1 Antibody (S04-3G4)

Immunogen

Recombinant protein of human KAT1 (Uniprot # O14929)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

45 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for KAT1 Antibody (S04-3G4)

Western Blot: KAT1 Antibody (S04-3G4) [NBP3-19521]

Western Blot: KAT1 Antibody (S04-3G4) [NBP3-19521]

Western Blot: KAT1 Antibody (S04-3G4) [NBP3-19521] - Western blot detection of KAT1/HAT1 in K562, C6, 3T3, Hela cell lysates using KAT1/HAT1 Rabbit mAb (1:1000 diluted). Predicted band size: 50kDa. Observed band size: 45kDa.
Immunohistochemistry-Paraffin: KAT1 Antibody (S04-3G4) [NBP3-19521]

Immunohistochemistry-Paraffin: KAT1 Antibody (S04-3G4) [NBP3-19521]

Immunohistochemistry-Paraffin: KAT1 Antibody (S04-3G4) [NBP3-19521] - Immunohistochemistry of KAT1/HAT1 in paraffin-embedded Human tonsil using KAT1/HAT1 Rabbit mAb at dilution 1/50

Applications for KAT1 Antibody (S04-3G4)

Application
Recommended Usage

Immunohistochemistry

1/200

Western Blot

1/1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: KAT1

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBPassociated factor), p300/CBP, HAT1, and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated RPD3) and HDAC3-6, have been identified as histone deacetylases.

Alternate Names

EC 2.3.1.48, histone acetyltransferase 1, histone acetyltransferase type B catalytic subunit, KAT1

Gene Symbol

HAT1

Additional KAT1 Products

Product Documents for KAT1 Antibody (S04-3G4)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for KAT1 Antibody (S04-3G4)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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