KAT4/TBP Associated Factor 1 Antibody (SR1493)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-22390

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-22390-100ul
NBP3-22390-50ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1493

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all KAT4/TBP Associated Factor 1 Antibodies »

Product Summary for KAT4/TBP Associated Factor 1 Antibody (SR1493)

Immunogen

A synthesized peptide derived from human KAT4/TBP Associated Factor 1 (Uniprot #: P21675)

Specificity

Detects endogenous levels of total KAT4/TBP Associated Factor 1

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

300 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for KAT4/TBP Associated Factor 1 Antibody (SR1493)

Western Blot: KAT4/TBP Associated Factor 1 Antibody (SR1493) [NBP3-22390] -

Western Blot: KAT4/TBP Associated Factor 1 Antibody (SR1493) [NBP3-22390] - Western blot analysis using NBP3-22390 in SH-SY5Y cell lysate.

Applications for KAT4/TBP Associated Factor 1 Antibody (SR1493)

Application
Recommended Usage

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: KAT4/TBP Associated Factor 1

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Two transcripts encoding different isoforms have been identified for this gene.

Long Name

Transcription initiation factor TFIID subunit 1

Alternate Names

BA2R, CCG1, CCGS, p250, TAF(II)250, TAF1, TAF2A, TAFII-250, TAFII250

Gene Symbol

TAF1

Additional KAT4/TBP Associated Factor 1 Products

Product Documents for KAT4/TBP Associated Factor 1 Antibody (SR1493)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for KAT4/TBP Associated Factor 1 Antibody (SR1493)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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