KCNJ1 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-04802

Novus Biologicals, part of Bio-Techne
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NBP3-04802-20ul
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Key Product Details

Species Reactivity

Validated:

Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all KCNJ1 Antibodies »

Product Summary for KCNJ1 Antibody - BSA Free

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 50-150 of human KCNJ1 (NP_000211.1). NIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVT

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for KCNJ1 Antibody - BSA Free

Western Blot: KCNJ1 AntibodyBSA Free [NBP3-04802]

Western Blot: KCNJ1 AntibodyBSA Free [NBP3-04802]

Western Blot: KCNJ1 Antibody [NBP3-04802] - Analysis of extracts of mouse kidney, using KCNJ1 antibody at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit .
Immunohistochemistry-Paraffin: KCNJ1 Antibody - BSA Free [NBP3-04802]

Immunohistochemistry-Paraffin: KCNJ1 Antibody - BSA Free [NBP3-04802]

Immunohistochemistry-Paraffin: KCNJ1 Antibody [NBP3-04802] - Paraffin-embedded rat pancreas using KCNJ1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry-Paraffin: KCNJ1 Antibody - BSA Free [NBP3-04802]

Immunohistochemistry-Paraffin: KCNJ1 Antibody - BSA Free [NBP3-04802]

Immunohistochemistry-Paraffin: KCNJ1 Antibody [NBP3-04802] - Paraffin-embedded rat testis using KCNJ1 antibody at dilution of 1:100 (40x lens).

Applications for KCNJ1 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:50-1:200

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS with 50% glycerol, pH7.3.

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: KCNJ1

FUNCTION: In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.; Tissue specificity: In the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver.; Subcellular location: Membrane, Multi-pass membrane protein.; Involvement in disease: Defects in KCNJ1 are the cause of Bartter syndrome type 2 (BS2) also termed hyperprostanglandin E syndrome 2. BS refers to a group of autosomal recessive disorders characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BS2 is a life-threatening condition beginning in utero, with marked fetal polyuria that leads to polyhydramnios and premature delivery. Another hallmark of BS2 is a marked hypercalciuria and, as a secondary consequence, the development of nephrocalcinosis and osteopenia.

Alternate Names

ATP-regulated potassium channel ROM-K, ATP-sensitive inward rectifier potassium channel 1, inwardly rectifying K+ channel, KIR1.1, potassium inwardly-rectifying channel, subfamily J, member 1, ROMK1inwardly rectifying subfamily J member 1

Gene Symbol

KCNJ1

Additional KCNJ1 Products

Product Documents for KCNJ1 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for KCNJ1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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