Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all KCNK18 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 17 amino acid synthetic peptide from near the center of human TRESK. The immunogen is located within amino acids 210 - 260 of TRESK. Amino Acid Squence: MELFERSHALEKQNTLQ

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

43.7 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for KCNK18 Antibody - BSA Free

Western Blot: KCNK18 AntibodyBSA Free [NBP1-77097]

Western Blot: KCNK18 AntibodyBSA Free [NBP1-77097]

Western Blot: KCNK18 Antibody [NBP1-77097] - Rat brain tissue lysate with KCNK18 antibody at (A) 1 and (B) 2 ug/mL
Immunohistochemistry-Paraffin: KCNK18 Antibody - BSA Free [NBP1-77097]

Immunohistochemistry-Paraffin: KCNK18 Antibody - BSA Free [NBP1-77097]

Immunohistochemistry-Paraffin: KCNK18 Antibody [NBP1-77097] - Rat brain tissue with KCNK18 antibody at 5 ug/mL.
KCNK18 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: KCNK18 Antibody - BSA Free [NBP1-77097] -

Immunocytochemistry/ Immunofluorescence: KCNK18 Antibody - BSA Free [NBP1-77097] - Immunofluorescence of KCNK18 in Rat Brain cells with KCNK18 antibody at 20 ug/mL.

Applications for KCNK18 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/ml

Immunohistochemistry

5 ug/ml

Immunohistochemistry-Paraffin

5 ug/ml

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: KCNK18

TRESK (TWIK-related spinal cord K+ channel) is a two-pore domain K+ channel that induces outward rectification and functions as a background K+ channel that is abundantly expressed in the spinal cord, thymus, spleen, and leukemic T-lymphocytes. TRESK is activated by increased cytoplasmic calcium concentration through calcineurin as well as by acetylcholine and histamine. It has been suggested that TRESK is linked to acute and chronic pain by activation of calcineurin. Other studies indicate that TRESK may play a role in the regulation of T-cell function and could be an excellent target to treat T-cell originated immune dysfunction.

Alternate Names

K2p18.1, potassium channel subfamily K member 18, potassium channel, subfamily K, member 18, TRESK2, TRESK-2, TRESKTWIK-related spinal cord potassium channel, TRIKMGR13, TWIK-related individual K+ channel, TWIK-related individual potassium channel, TWIK-related spinal cord K+ channel

Entrez Gene IDs

338567 (Human)

Gene Symbol

KCNK18

UniProt

Q7Z418 (Human)

Additional KCNK18 Products

Product Documents for KCNK18 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for KCNK18 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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