KIR2DL4/CD158d Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-17062

Novus Biologicals, part of Bio-Techne
Catalog #
Availability
Size / Price
Qty
NBP2-17062
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Primate (96%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all KIR2DL4/CD158d Antibodies »

Product Specifications

Immunogen

Recombinant protein encompassing a sequence within the center region of human KIR2DL4/CD158d. The exact sequence is proprietary.

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Rhesus MonkeyMonkey (89%), Chimpanzee (96%).

Localization

Cell membrane; Single-pass type I membrane protein

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

41 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for KIR2DL4/CD158d Antibody

Western Blot: KIR2DL4/CD158d Antibody [NBP2-17062]

Western Blot: KIR2DL4/CD158d Antibody [NBP2-17062]

Western Blot: KIR2DL4/CD158d Antibody [NBP2-17062] - Sample (30 ug of whole cell lysate) A: THP-1 10% SDS PAGE gel, diluted at 1:1000.
Immunocytochemistry/ Immunofluorescence: KIR2DL4/CD158d Antibody [NBP2-17062]

Immunocytochemistry/ Immunofluorescence: KIR2DL4/CD158d Antibody [NBP2-17062]

Immunocytochemistry/Immunofluorescence: KIR2DL4/CD158d Antibody [NBP2-17062] - HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: KIR2DL4 protein stained by KIR2DL4 antibody diluted at 1:500. Blue: Hoechst 33342 staining.
Immunohistochemistry-Paraffin: KIR2DL4/CD158d Antibody [NBP2-17062]

Immunohistochemistry-Paraffin: KIR2DL4/CD158d Antibody [NBP2-17062]

Immunohistochemistry-Paraffin: KIR2DL4/CD158d Antibody [NBP2-17062] - Human breast cancer, using KIR2DL4 antibody at 1:250 dilution. Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

Applications for KIR2DL4/CD158d Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:100-1:1000

Immunohistochemistry

1:100-1:1000

Immunohistochemistry-Paraffin

1:100-1:1000

Western Blot

1:500-1:3000

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

0.1M Tris (pH 7), 0.1M Glycine, 10% Glycerol

Preservative

0.01% Thimerosal

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: KIR2DL4/CD158d

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternative splicing results in multiple transcript variants. [provided by RefSeq]

Long Name

Killer Cell Immunoglobulin-like Receptor, Two Domain Long Cytoplasmic Tail, 4

Alternate Names

CD158d

Gene Symbol

KIR2DL4

UniProt

Q99706

Additional KIR2DL4/CD158d Products

Product Documents for KIR2DL4/CD158d Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for KIR2DL4/CD158d Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

Privacy and Cookie Policy
Site Map
© Copyright 2024 Bio-Techne. All Rights Reserved.