Kir3.1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-14384

Novus Biologicals, part of Bio-Techne
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NBP3-14384
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Avian (94%), Bovine (100%), Chicken (94%), Equine (100%), Guinea Pig (100%), Hamster (100%), Monkey (100%), Mouse (100%), Porcine (100%), Primate (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit

Concentration

1 mg/ml

View all Kir3.1 Antibodies »

Product Specifications

Immunogen

Synthetic 16 amino acid peptide from internal region of human Kir3.1.

Epitope

Internal

Reactivity Notes

Expected reactivity based on percent sequence identity: Bat (88%), Xenopus (81%)

Specificity

Human Kir3.1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Clonality

Polyclonal

Host

Rabbit

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for Kir3.1 Antibody

Immunohistochemistry-Paraffin: Kir3.1 Antibody [NBP3-14384]

Immunohistochemistry-Paraffin: Kir3.1 Antibody [NBP3-14384]

Immunohistochemistry-Paraffin: Kir3.1 Antibody [NBP3-14384] - Immunohistochemistry of formalin-fixed, paraffin-embedded human heart after heat-induced antigen retrieval.

Applications for Kir3.1 Antibody

Application
Recommended Usage

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Preservative

0.1% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: Kir3.1

G protein-coupled inwardly rectifying potassium channels (KIR3.1 through KIR3.4) are coupled to numerous neurotransmitter receptors in the brain and are abundantly expressed in the olfactory bulb, hippocampus, neocortex, dentate gyrus, cerebellar cortex and thalamus regions of the brain. Also known as GIRK, KIR3 potassium channels localize to the soma and dendrites as well as axons of neurons. Liberated Gbgamma subunits from G protein heterotrimers bind to and regulate KIR3 channel activity. Gb3- and Gb4-containing Gbgamma dimers bind directly to cytoplasmic domains of KIR3 proteins and increase the K+ current while Gb5-containing Gbgamma dimers inhibit KIR3 K+ current. KIR3 activity is also inhibited by tyrosine phosphorylation. Brain-derived neurotrophic factor activates receptor tyrosine kinase B, which then phosphorylates KIR3 tyrosine residues, effectively inactivating the KIR3 channels.

Long Name

G protein-activated inward rectifier potassium channel 1

Alternate Names

GIRK-1, GIRK1, KCNJ3

Gene Symbol

KCNJ3

Additional Kir3.1 Products

Product Documents for Kir3.1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Kir3.1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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