Kirrel1/NEPH1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-12277

Novus Biologicals, part of Bio-Techne
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NBP3-12277
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Key Product Details

Species Reactivity

Mouse, Rat

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Kirrel1/NEPH1 Antibodies »

Product Specifications

Immunogen

Synthetic peptide taken within amino acid region 200-250 on mouse Neph1 protein.

Clonality

Polyclonal

Host

Rabbit

Scientific Data Images for Kirrel1/NEPH1 Antibody

Immunohistochemistry-Paraffin: Kirrel1/NEPH1 Antibody [NBP3-12277]

Immunohistochemistry-Paraffin: Kirrel1/NEPH1 Antibody [NBP3-12277]

Immunohistochemistry-Paraffin: Kirrel1/NEPH1 Antibody [NBP3-12277] - Mouse Kidney. 1:100 dilution IHC blocking buffer. DAB (brown) staining and Hematoxylin QS (blue) counterstain. 40X magnification.

Applications for Kirrel1/NEPH1 Antibody

Application
Recommended Usage

ELISA

1:10000

Immunocytochemistry/ Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunohistochemistry-Paraffin

1:250

Immunoprecipitation

1:250

Western Blot

1:250

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

Contains Tris, HCl/glycine buffer (pH 7.4-7.8), 30% glycerol, 0.5% BSA, along with cryo-protective agents, and HEPES (exact storage and stabilization buffer information is proprietary).

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Store at -20C long term. Avoid freeze-thaw cycles.

Background: Kirrel1/NEPH1

Kirrel (kin of irregular chiasm-1-like) proteins, also known as the NEPH (nephrin-like) family, are type I transmembrane glycoproteins within the immunoglobulin superfamily. Kirrel1 (NEPH1), Kirrel2 (NEPH3, Filtrin, NLG-1) and Kirrel3 (NEPH2, kirre) share 34 - 44% amino acid (aa) identity, and all interact with nephrin, podocin and the adaptor molecule ZO-1 (1, 4). All can be found in podocytes of the kidney glomerulus, and play a role in barrier function in the slit diaphragm. (2-6). Kirrel1 can also be found in central nervous system neurons, pancreas and placenta, Kirrel2 in pancreatic islet beta cells, brain and lymph nodes, and Kirrel3 in the brain and bone marrow, typically at sites where nephrin is also expressed.

Long Name

Kin of Irregular Chiasm-like 1

Alternate Names

KIRREL, NEPH1

Gene Symbol

KIRREL1

Additional Kirrel1/NEPH1 Products

Product Documents for Kirrel1/NEPH1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Kirrel1/NEPH1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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