KMT3B/NSD1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-1744

Novus Biologicals, part of Bio-Techne
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NB100-1744
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.25 mg/ml

View all KMT3B/NSD1 Antibodies »

Product Specifications

Immunogen

The immunogen recognized by this antibody maps to a region between residue 650 and 700 of human NSD1 using the numbering given in SwissProt entry Q96L73 (GeneID 64324).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for KMT3B/NSD1 Antibody

Immunohistochemistry-Paraffin: KMT3B/NSD1 Antibody [NB100-1744]

Immunohistochemistry-Paraffin: KMT3B/NSD1 Antibody [NB100-1744]

Immunohistochemistry-Paraffin: KMT3B/NSD1 Antibody [NB100-1744] - Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-NSD1 used at a dilution of 1:250. Detection: DAB staining using Immunohistochemistry Accessory Kit .
Immunohistochemistry-Paraffin: KMT3B/NSD1 Antibody [NB100-1744]

Immunohistochemistry-Paraffin: KMT3B/NSD1 Antibody [NB100-1744]

Immunohistochemistry-Paraffin: KMT3B/NSD1 Antibody [NB100-1744] - Sample : FFPE section of human prostate adenocarcinoma. Antibody: Affinity purified rabbit anti-NSD1 used at a dilution of 1:250. Detection: DAB

Applications for KMT3B/NSD1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:100 - 1:500

Immunohistochemistry-Paraffin

1:100 - 1:500
Application Notes
Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining. Likely to work with frozen sections.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

TBS and 0.1% BSA

Preservative

0.09% Sodium Azide

Concentration

0.25 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: KMT3B/NSD1

KMT3B/NSD1 is a histone methyltransferase that preferentially methylates Lys-36 of histone H3 and Lys-20 of histone H4. KMT3B/NSD1 can function as an androgen receptor coactivator and is capable of both negatively and positively influencing transcription. Mutations in KMT3B/NSD1 are responsible for Sotos syndrome, Weaver syndrome, Beckwith-Wiedemann syndrome, and a form of childhood leukemia. Alternate names for KMT3B/NSD1 include nuclear receptor binding SET domain protein 1, ARA267, ARA-267 androgen receptor-associated coregulator 267, STO, SOTOS, Sotos syndrome, and FLJ22263.

Alternate Names

Androgen receptor coactivator 267 kDa protein, Androgen receptor-associated protein of 267 kDa, ARA267STO, DKFZp666C163, EC 2.1.1.43, FLJ10684, FLJ22263, FLJ44628, H3 lysine-36 and H4 lysine-20 specific, KMT3BSotos syndrome, Lysine N-methyltransferase 3B, NR-binding SET domain-containing protein, nuclear receptor binding SET domain protein 1

Entrez Gene IDs

64324 (Human)

Gene Symbol

NSD1

UniProt

Q96L73 (Human)

Additional KMT3B/NSD1 Products

Product Documents for KMT3B/NSD1 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for KMT3B/NSD1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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