KRIT1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-19307

Novus Biologicals, part of Bio-Techne
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NBP2-19307
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (98%), Chicken (93%), Mouse (94%), Rat (95%), Rhesus Macaque (99%). Backed by our 100% Guarantee.

Applications

Electron Microscopy, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all KRIT1 Antibodies »

Product Summary for KRIT1 Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human KRIT1. The exact sequence is proprietary.

Reactivity Notes

Zebrafish (82%).

Localization

Membrane; Peripheral membrane protein

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

84 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for KRIT1 Antibody

Western Blot: KRIT1 Antibody [NBP2-19307]

Western Blot: KRIT1 Antibody [NBP2-19307]

Western Blot: KRIT1 Antibody [NBP2-19307] - Sample (30 ug of whole cell lysate) A: Raji 7. 5% SDS PAGE gel, diluted at 1:1000.

Applications for KRIT1 Antibody

Application
Recommended Usage

Electron Microscopy

1:10 - 1:500

Western Blot

1:500-1:3000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

0.1M Tris (pH 7), 0.1M Glycine, 20% Glycerol

Preservative

0.01% Thimerosal

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: KRIT1

This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]

Alternate Names

CAMcerebral cavernous malformations 1, CCM1ankyrin repeat-containing protein Krit1, Cerebral cavernous malformations 1 protein, Krev interaction trapped 1, krev interaction trapped protein 1, KRIT1, ankyrin repeat containing

Gene Symbol

KRIT1

UniProt

O00522 (Human)

Additional KRIT1 Products

Product Documents for KRIT1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for KRIT1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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