Kv11.1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-14389

Novus Biologicals, part of Bio-Techne
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NBP3-14389
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bat (100%), Canine (94%), Equine (94%), Monkey (100%), Mouse (100%), Primate (100%), Rabbit (94%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit

Concentration

0.9 mg/ml

View all Kv11.1 Antibodies »

Product Specifications

Immunogen

Synthetic 17 amino acid peptide from internal region of human Kv11.1.

Epitope

Internal

Reactivity Notes

Expected reactivity based on percent sequence identity: Hamster (82%)

Specificity

Human Kv11.1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Clonality

Polyclonal

Host

Rabbit

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for Kv11.1 Antibody

Immunohistochemistry-Paraffin: Kv11.1 Antibody [NBP3-14389]

Immunohistochemistry-Paraffin: Kv11.1 Antibody [NBP3-14389]

Immunohistochemistry-Paraffin: Kv11.1 Antibody [NBP3-14389] - Immunohistochemistry of formalin-fixed, paraffin-embedded human cerebellum after heat-induced antigen retrieval.

Applications for Kv11.1 Antibody

Application
Recommended Usage

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Preservative

0.1% Sodium Azide

Concentration

0.9 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: Kv11.1

Human ether-a-go-go related gene (HERG) encodes the pore-forming subunit of the delayed rectifier potassium channel IKr. There are two N-terminal splice variants of HERG include the full-length isoform 1 alpha and the shorter isoform 1 beta. Isoform 1 beta lacks the PAS motif and deactivates at a faster rate than isoform 1alpha. Residues within the C-terminal play a role in channel expression and channel gating, including voltage-dependent activation. HERG is expressed in the heart and is more abundantly expressed in the ventricles than in the atria. Mutations in the gene encoding HERG increase beat-to-beat variability and early after depolarization. These fluctuations facilitate the genesis and propagation of premature heartbeats associated with inheritable long QT syndrome type 2 and short QT syndrome type 1.

Long Name

Potassium voltage-gated channel subfamily H member 2

Alternate Names

Eag homolog, ERG, ERG-1, ERG1, H-ERG, HERG, hERG-1, hERG1, KCNH2

Gene Symbol

KCNH2

Additional Kv11.1 Products

Product Documents for Kv11.1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Kv11.1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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