Kv7.1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-31876

Novus Biologicals, part of Bio-Techne
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NBP2-31876
NBP2-31876-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Kv7.1 Antibodies »

Product Summary for Kv7.1 Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: PRSHTLLSPSPKPKKSVVVKKKKFKLDKDNGVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFMRTNSFAEDLDLEGETLLTPITHISQLREHHRATIKVIRR

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (88%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Kv7.1 Antibody

Immunohistochemistry-Paraffin: Kv7.1 Antibody [NBP2-31876]

Immunohistochemistry-Paraffin: Kv7.1 Antibody [NBP2-31876]

Immunohistochemistry-Paraffin: Kv7.1 Antibody [NBP2-31876] - Staining of human skin shows low expression as expected.
Immunohistochemistry-Paraffin: Kv7.1 Antibody [NBP2-31876]

Immunohistochemistry-Paraffin: Kv7.1 Antibody [NBP2-31876]

Immunohistochemistry-Paraffin: Kv7.1 Antibody [NBP2-31876] - Staining of human adrenal gland shows high expression.
Immunohistochemistry-Paraffin: Kv7.1 Antibody [NBP2-31876]

Immunohistochemistry-Paraffin: Kv7.1 Antibody [NBP2-31876]

Immunohistochemistry-Paraffin: Kv7.1 Antibody [NBP2-31876] - Staining in human adrenal gland and skin tissues using anti-KCNQ1 antibody. Corresponding KCNQ1 RNA-seq data are presented for the same tissues.

Applications for Kv7.1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Kv7.1

KCNQ1 encodes a protein for a voltage-gated potassium channel required for the repolarization phase of the cardiac action potential. The gene product can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome, Romano-Ward syndrome, Jervell and Lange-Nielsen syndrome and familial atrial fibrillation. The gene is located in a region of chromosome 11 that contains a large number of contiguous genes that are abnormally imprinted in cancer and the Beckwith-Wiedemann syndrome. Two alternative transcripts encoding distinct isoforms have been described (from EntrezGene).

Long Name

Potassium voltage-gated channel subfamily KQT member 1

Alternate Names

KCNA8, KCNA9, KCNQ1, KQT-like 1, KVLQT1

Gene Symbol

KCNQ1

UniProt

P51787 (Human)

Additional Kv7.1 Products

Product Documents for Kv7.1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Kv7.1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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