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Kv7.3 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-36967

Novus Biologicals, part of Bio-Techne
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NBP1-36967

Key Product Details

Species Reactivity

Human, Mouse, Rat, Porcine

Applications

Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

Product Specifications

Immunogen

Peptide with sequence C-SDSVWTPSNKPI corresponding to C-Terminus according to NP_004510.1.

Epitope

C-Terminus

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Description

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Applications for Kv7.3 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:16000
Application Notes
WB: Preliminary experiments gave an approx. 23 kDa band in human brain (cerebral cortex, amygdala, hippocampus) lysates after 0.3ug/ml antibody staining. Please note that currently we can not find an explanation in the literature for the band we observe given the calculated size of 96.7 kDa band according to NP_004510.1. The 23 kDa band was successfully blocked by incubation with the immunizing peptide.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Kv7.3

KCNQ3 is a gene that codes for a protein with two isoforms, measuring 872 and 752 amino acids in length, with weights of approximately 97 and 85 kDa respectively. KCNQ3 is thought to be important in the regulation of neuronal excitability. Current studies are being done one several diseases and disorders linked to this gene including convulsions, myokymia with neonatal epilepsy, juvenile myoclonic epilepsy, generalized epilepsy, benign neonatal seizures, neuronitis, migraine, pharyngitis, and ataxia. KCNQ3 has also been shown to have interactions with CALM1, CALM2, CALM3, KCNQ4, and KCNQ2 in pathways such as the synaptic transmission-ion currents, L1CAM interactions, potassium channels, and celecoxib pathways.

Long Name

Potassium voltage-gated channel subfamily KQT member 3

Alternate Names

KCNQ3, KQT-like 3

Entrez Gene IDs

3786 (Human); 110862 (Mouse); 29682 (Rat)

Gene Symbol

KCNQ3

Additional Kv7.3 Products

Product Documents for Kv7.3 Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Kv7.3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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