LAIR1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-84590

Novus Biologicals, part of Bio-Techne
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NBP1-84590
NBP1-84590-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

IF/IHC

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all LAIR1 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: HRQNQIKQGPPRSKDEEQKPQQRPDLAVDVLERTADKATVNGLPEKDRETDTSALAAGSSQEVTYAQLDHWALTQRTARAVSPQSTKPMAESITYAAVARH

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for LAIR1 Antibody

Immunohistochemistry-Paraffin: LAIR1 Antibody [NBP1-84590]

Immunohistochemistry-Paraffin: LAIR1 Antibody [NBP1-84590]

Immunohistochemistry-Paraffin: LAIR1 Antibody [NBP1-84590] - Analysis in human lymph node and pancreas tissues. Corresponding LAIR1 RNA-seq data are presented for the same tissues.
Western Blot: LAIR1 Antibody [NBP1-84590]

Western Blot: LAIR1 Antibody [NBP1-84590]

Western Blot: LAIR1 Antibody [NBP1-84590] - Analysis in human cell line THP-1.
Immunocytochemistry/ Immunofluorescence: LAIR1 Antibody [NBP1-84590]

Immunocytochemistry/ Immunofluorescence: LAIR1 Antibody [NBP1-84590]

Immunocytochemistry/Immunofluorescence: LAIR1 Antibody [NBP1-84590] - Staining of human cell line U-251 MG shows localization to plasma membrane. Antibody staining is shown in green.
View 4 more images

Applications for LAIR1 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: LAIR1

LAIR1 is a transmembrane glycoprotein(approx. 32kDa) expressed on the majority of human peripheral blood mononuclear leukocytes including T cells, B cells, NK cells, macrophages and dendritic cells. LAIR1 recruits SHP1 and SHP2 tyrosine phosphatases upon activation, and cross-linking of the LAIR1 molecule on NK cells results in strong inhibition of NK cell mediated cytotoxicity. This clone is reported to inhibit NK cell triggering via CD16 molecules.

Long Name

Leukocyte-associated Ig-like Receptor 1

Alternate Names

CD305, HLAIR1, LAIR-1

Gene Symbol

LAIR1

Additional LAIR1 Products

Product Documents for LAIR1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for LAIR1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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