Laminin S/Laminin beta 2 Antibody (CL2979)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-42387

Novus Biologicals, part of Bio-Techne
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NBP2-42387
NBP2-42387-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # CL2979

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Laminin S Antibodies »

Product Summary for Laminin S/Laminin beta 2 Antibody (CL2979)

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: DLTDVQDENFNANHALSGLERDRLALNLTLRQLDQHLDLLKHSNFLGAYDSIRHAHSQSAEAERRANTSALAVPSPVSNSASARHRTEALMDAQKEDFNSKHMANQRALGKLSAHTHTLSLTDINELVCGAPG

Epitope

NANHALSGLERDRLA

Reactivity Notes

Expected to cross react based on sequence identity: Rat (82%), Mouse (83%).

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Scientific Data Images for Laminin S/Laminin beta 2 Antibody (CL2979)

Immunohistochemistry-Paraffin: Laminin S/Laminin beta 2 Antibody (CL2979) [NBP2-42387]

Immunohistochemistry-Paraffin: Laminin S/Laminin beta 2 Antibody (CL2979) [NBP2-42387]

Immunohistochemistry-Paraffin: Laminin S/Laminin beta 2 Antibody (CL2979) [NBP2-42387] - Staining in human heart muscle and tonsil tissues. Corresponding LAMB2 RNA-seq data are presented for the same tissues.
Western Blot: Laminin S/Laminin beta 2 Antibody (CL2979) [NBP2-42387]

Western Blot: Laminin S/Laminin beta 2 Antibody (CL2979) [NBP2-42387]

Western Blot: Laminin S/Laminin beta 2 Antibody (CL2979) [NBP2-42387] - Analysis of purified human recombinant Laminin-421, Laminin-521, Laminin-332 and Laminin-111.
Western Blot: Laminin S/Laminin beta 2 Antibody (CL2979) [NBP2-42387]

Western Blot: Laminin S/Laminin beta 2 Antibody (CL2979) [NBP2-42387]

Western Blot: Laminin S/Laminin beta 2 Antibody (CL2979) [NBP2-42387] - Analysis in human lung tissue.
View 4 more images

Applications for Laminin S/Laminin beta 2 Antibody (CL2979)

Application
Recommended Usage

Immunohistochemistry

1:2500 - 1:5000

Immunohistochemistry-Paraffin

1:2500 - 1:5000

Western Blot

1 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Laminin S

The Laminins comprise a growing family of disulfide-linked heterotrimers consisting of three genetically distinct polypeptide chains, designated alpha, beta and gamma. A major component of the basal lamina, Laminins play a crucial role in providing a scaffolding upon which tissues are assembled and which serves as a physical barrier separating specialized tissues. During embryogenesis and early development, cells migrate along basement membranes, which are required for the polarization of cells. The beta-2 laminin chain plays a role in melanoma spread, promoting tumor migration along the abluminal surface of vessel, a phenomenon which has been termed extra-vascular migratory metastasis.

Long Name

Laminin, beta 2

Alternate Names

LAMB2, Laminin beta 2

Gene Symbol

LAMB2

UniProt

P55268 (Human)

Additional Laminin S Products

Product Documents for Laminin S/Laminin beta 2 Antibody (CL2979)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Laminin S/Laminin beta 2 Antibody (CL2979)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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