LATS1 Antibody (3A7)

Novus Biologicals, part of Bio-Techne | Catalog # H00009113-M09

Novus Biologicals, part of Bio-Techne
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H00009113-M09
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Sandwich ELISA, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2a Kappa Clone # 3A7

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all LATS1 Antibodies »

Product Specifications

Immunogen

LATS1 (NP_004681, 521 a.a. ~ 620 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.PQPIQTVQPSPFPEGTASNVTVMPPVAEAPNYQGPPPPYPKHLLHQNPSVPPYESISKPSKEDQPSLPKEDESEKSYENVDSGDKEKKQITTSPITVRKN

Specificity

LATS1 - LATS, large tumor suppressor, homolog 1 (Drosophila) (3A7)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2a Kappa

Scientific Data Images for LATS1 Antibody (3A7)

Western Blot: LATS1 Antibody (3A7) [H00009113-M09]

Western Blot: LATS1 Antibody (3A7) [H00009113-M09]

Western Blot: LATS1 Antibody (3A7) [H00009113-M09] - S1 monoclonal antibody (M09), clone 3A7. Western Blot analysis of LATS1 expression in HeLa ( Cat # L013V1 ).
Sandwich ELISA: LATS1 Antibody (3A7) [H00009113-M09] - Detection limit for recombinant GST tagged LATS1 is approximately 10ng/ml as a capture antibody.

Applications for LATS1 Antibody (3A7)

Application
Recommended Usage

Western Blot

1:500
Application Notes
Antibody reactive against cell lysate and recombinant protein for western blot. It has also been used for ELISA.

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: LATS1

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq]

Alternate Names

EC 2.7.11, h-warts, Large tumor suppressor homolog 1, LATS (large tumor suppressor, Drosophila) homolog 1, LATS, large tumor suppressor, homolog 1 (Drosophila), serine/threonine-protein kinase LATS1, WARTS protein kinase, WARTSEC 2.7.11.1, wts

Entrez Gene IDs

9113 (Human)

Gene Symbol

LATS1

UniProt

NP_004681 (Human)

Additional LATS1 Products

Product Documents for LATS1 Antibody (3A7)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for LATS1 Antibody (3A7)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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