Legumain encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq]

Alternate Names

AEP, Asparaginyl Endopeptidase, LGMN

Gene Symbol

LGMN

UniProt

Q99538

Additional Legumain/Asparaginyl Endopeptidase Products

Product Documents

Product Datasheets

Download Product Datasheets

COA

SDS

Download SDS

Product Specific Notices

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations
Reviews

Legumain/Asparaginyl Endopeptidase Antibody (46I3) - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-21996

Key Product Details

Species Reactivity

Validated:

Applications

Label

Antibody Source

Format

Concentration

View all Legumain/Asparaginyl Endopeptidase Antibodies »

Product Summary

Immunogen

Clonality

Host

Isotype

Scientific Data Images

Western Blot: Legumain/Asparaginyl Endopeptidase Antibody (46I3)Azide and BSA Free [NBP2-21996]

Applications

ELISA

Western Blot

Formulation, Preparation, and Storage

Purification

Reconstitution

Formulation

Format

Preservative

Concentration

Shipping

Stability & Storage

Background: Legumain/Asparaginyl Endopeptidase