Lgi4 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-76380

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all Lgi4 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 14 amino acid synthetic peptide from near the center of human LGI4. The immunogen is located within amino acids 240 - 290 of LGI4. Amino Acid Squence: YSLQRFRPEEELPA

Specificity

Two isoforms of LGI4 are known to exist; this LGI4 antibody will recognize only the larger form. This LGI4 antibody is predicted to be specific to LGI4 and not recognize other LGI proteins.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Lgi4 Antibody - BSA Free

Western Blot: Lgi4 AntibodyBSA Free [NBP1-76380]

Western Blot: Lgi4 AntibodyBSA Free [NBP1-76380]

Western Blot: Lgi4 Antibody [NBP1-76380] - Human brain tissue lysate with LGI4 antibody at (A) 1 and (B) 2 ug/mL.

Applications for Lgi4 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Lgi4

The leucine-rich, glioma inactivated gene 4 (LGI4) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI4 have not been found to be associated with ADTLE. However, the LGI4 gene is located in a region linked to benign familial infantile convulsions. Further study revealed that a GC-to-AT polymorphism was correlated with childhood absence epilepsy. Other studies showed that decreasing LGI4 expression in cultured cells inhibits myelination, indicating that LGI4 may play a role in neural development. Two isoforms of LGI4 are known to exist; this LGI4 antibody will recognize only the larger form. This LGI4 antibody is predicted to be specific to LGI4 and not recognize other LGI proteins.

Alternate Names

leucine-rich glioma-inactivated gene 4, Leucine-rich glioma-inactivated protein 4, leucine-rich repeat LGI family member 4, leucine-rich repeat LGI family, member 4, LGI1-like protein 3, LGIL3

Gene Symbol

LGI4

UniProt

AAM49552 (Human)

Additional Lgi4 Products

Product Documents for Lgi4 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Lgi4 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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