LIMPII/SR-B2 Antibody (7D2P5)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-16779

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-16779-100ul
NBP3-16779-20ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 7D2P5

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all LIMPII/SR-B2 Antibodies »

Product Summary for LIMPII/SR-B2 Antibody (7D2P5)

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SR-B2/LIMPII/SR-B2 (Q14108). MGRCCFYTAGTLSLLLLVTSVTLLVARVFQKAVDQSIEKKIVLRNGTEAFDSWEKPPLPVYTQFYFFNVTNPEEILRGETPRVEEVGPYTYRELRNKANI

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for LIMPII/SR-B2 Antibody (7D2P5)

Western Blot: LIMPII/SR-B2 Antibody (7D2P5) [NBP3-16779]

Western Blot: LIMPII/SR-B2 Antibody (7D2P5) [NBP3-16779]

Western Blot: LIMPII/SR-B2 Antibody (7D2P5) [NBP3-16779] - Western blot analysis of extracts of various cell lines, using SR-B2/LIMPII/SR-B2 Rabbit mAb (NBP3-16779) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Immunohistochemistry-Paraffin: LIMPII/SR-B2 Antibody (7D2P5) [NBP3-16779]

Immunohistochemistry-Paraffin: LIMPII/SR-B2 Antibody (7D2P5) [NBP3-16779]

Immunohistochemistry-Paraffin: LIMPII/SR-B2 Antibody (7D2P5) [NBP3-16779] - Immunohistochemistry of paraffin-embedded mouse liver using SR-B2/LIMPII/SR-B2 Rabbit mAb (NBP3-16779) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
Immunohistochemistry-Paraffin: LIMPII/SR-B2 Antibody (7D2P5) [NBP3-16779]

Immunohistochemistry-Paraffin: LIMPII/SR-B2 Antibody (7D2P5) [NBP3-16779]

Immunohistochemistry-Paraffin: LIMPII/SR-B2 Antibody (7D2P5) [NBP3-16779] - Immunohistochemistry of paraffin-embedded rat lung using SR-B2/LIMPII/SR-B2 Rabbit mAb (NBP3-16779) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
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Applications for LIMPII/SR-B2 Antibody (7D2P5)

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Western Blot

1:500 - 1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 0.05% BSA, 50% glycerol, pH7.3

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: LIMPII/SR-B2

High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII differs from SR-BI in that the encoded c-terminal cytoplasmic domain is almost completely different. SR-BII binds HDLs and mediates selective uptake of HDL cholesteryl ester, but with an approximately 4-fold lower efficiency than SR-BI. Nuclease protection assays show SR-BII to be abundant in mouse tissues expressing SR-BI, with SR-BII expression found in liver, adrenal glands, and testes. Although the role of SR-BII is not completely clear, research suggests that it may be a functional HDL receptor. In addition, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with the SR-BII isoform mediating selective transfer of lipid between HDL and cells. The relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.

Long Name

Lysosomal Integral Membrane Protein II

Alternate Names

CD36L2, LPG85, SCARB2, SR-B2, SR-BII, SRB2

Gene Symbol

SCARB2

Additional LIMPII/SR-B2 Products

Product Documents for LIMPII/SR-B2 Antibody (7D2P5)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for LIMPII/SR-B2 Antibody (7D2P5)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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