LIN7C Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-53082

Novus Biologicals, part of Bio-Techne
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NBP1-53082
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all LIN7C Antibodies »

Product Specifications

Immunogen

Synthetic peptides corresponding to LIN7C(lin-7 homolog C (C. elegans)) The peptide sequence was selected from the N terminal of LIN7C. Peptide sequence MAALGEPVRLERDICRAIELLEKLQRSGEVPPQKLQALQRVLQSEFCNAV. The peptide sequence for this immunogen was taken from within the described region.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

The addition of 50% glycerol is optional for those storing this antibody at -20C and not aliquoting smaller units. However, please note that glycerol may interrupt some downstream antibody applications and should be added with caution.

Scientific Data Images for LIN7C Antibody

Western Blot: LIN7C Antibody [NBP1-53082]

Western Blot: LIN7C Antibody [NBP1-53082]

Western Blot: LIN7C Antibody [NBP1-53082] - HepG2 cell lysate, concentration 1 ug/ml.
Immunohistochemistry-Paraffin: LIN7C Antibody [NBP1-53082]

Immunohistochemistry-Paraffin: LIN7C Antibody [NBP1-53082]

Immunohistochemistry-Paraffin: LIN7C Antibody [NBP1-53082] - Human Colon Tissue, antibody concentration 5 ug/ml.

Applications for LIN7C Antibody

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

1:10-1:500

Western Blot

1.0 ug/ml

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 2% Sucrose

Preservative

0.09% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: LIN7C

LIN7C plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. It forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. LIN7C ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. It is also required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

Alternate Names

FLJ11215, lin-7 homolog C (C. elegans), Lin-7C, LIN-7-C, MALS-3LIN-7 protein 3, MALS3protein lin-7 homolog C, Mammalian lin-seven protein 3, veli-3, VELI3Lin7c, Vertebrate lin-7 homolog 3

Gene Symbol

LIN7C

UniProt

Q9NUP9 (Human)

Additional LIN7C Products

Product Documents for LIN7C Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for LIN7C Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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