Lipin 2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-00525

Novus Biologicals, part of Bio-Techne
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NBP3-00525
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Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all Lipin 2 Antibodies »

Product Specifications

Immunogen

Peptide with sequence CYWRDPIPEVDLDDLS corresponding to C-Terminus according to NP_055461.1.

Epitope

CYWRDPIPEVDLDDLS

Reactivity Notes

Expected from sequence similarity: Mouse, Rat, Porcine

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Lipin 2 Antibody

Immunocytochemistry/ Immunofluorescence: Lipin 2 Antibody [NBP3-00525]

Immunocytochemistry/ Immunofluorescence: Lipin 2 Antibody [NBP3-00525]

Immunocytochemistry/Immunofluorescence: Lipin 2 Antibody [NBP3-00525] - Immunofluorescence analysis of paraformaldehyde fixed U2OS cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor (TM) 488 secondary antibody (2ug/ml), showing cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor (TM) 488 secondary antibody (2ug/ml).
Flow Cytometry: Lipin 2 Antibody [NBP3-00525]

Flow Cytometry: Lipin 2 Antibody [NBP3-00525]

Flow Cytometry: Lipin 2 Antibody [NBP3-00525] - Flow cytometric analysis of paraformaldehyde fixed A431 cells (blue line), permeabilized with 0.5% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor (TM) 488 secondary antibody (1ug/ml). IgG control: Unimmunized goat IgG (black line) followed by Alexa Fluor (TM) 488 secondary antibody.
Immunocytochemistry/ Immunofluorescence: Lipin 2 Antibody [NBP3-00525]

Immunocytochemistry/ Immunofluorescence: Lipin 2 Antibody [NBP3-00525]

Immunocytochemistry/Immunofluorescence: Lipin 2 Antibody [NBP3-00525] - Immunofluorescence analysis of paraformaldehyde fixed A431 cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor (TM) 488 secondary antibody (2ug/ml), showing cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor (TM) 488 secondary antibody (2ug/ml).

Applications for Lipin 2 Antibody

Application
Recommended Usage

Flow Cytometry

10 ug/mL

Immunocytochemistry/ Immunofluorescence

10 ug/mL

Peptide ELISA

Detection limit 1:8000
Application Notes
Immunofluorescence: Strong expression of the protein seen in the cytoplasm of A431 and U2OS cells.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Lipin 2

Lipin 2 plays important roles in controlling the metabolism of fatty acids at differents levels. Lipin 2 acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Lipin 2 also acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism By similarity. Defects in LPIN2 are the cause of Majeed syndrome (MAJEEDS) . An autosomal recessive syndrome characterized by chronic recurrent multifocal osteomyelitis that is of early onset with a lifelong course, congenital dyserythropoietic anemia that presents as hypochromic, microcytic anemia during the first year of life and ranges from mild to transfusion-dependent, and transient inflammatory dermatosis, often manifesting as Sweet syndrome (neutrophilic skin infiltration).

Long Name

Phosphatidate Phosphatase LPIN2

Alternate Names

LPIN2

Gene Symbol

LPIN2

Additional Lipin 2 Products

Product Documents for Lipin 2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Lipin 2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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