LKB1/STK11 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-87817

Novus Biologicals, part of Bio-Techne
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NBP1-87817
NBP1-87817-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Predicted:

Mouse (99%), Rat (99%). Backed by our 100% Guarantee.

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

IF/IHC

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all LKB1/STK11 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: DSTEVIYQPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQ

Reactivity Notes

Human reactivity reported in scientific literature (PMID: 25042259).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for LKB1/STK11 Antibody

Immunohistochemistry-Paraffin: LKB1/STK11 Antibody [NBP1-87817]

Immunohistochemistry-Paraffin: LKB1/STK11 Antibody [NBP1-87817]

Immunohistochemistry-Paraffin: LKB1/STK11 Antibody [NBP1-87817] - Staining of human skeletal muscle shows moderate to strong cytoplasmic positivity in myocytes.
Immunohistochemistry-Paraffin: LKB1/STK11 Antibody [NBP1-87817]

Immunohistochemistry-Paraffin: LKB1/STK11 Antibody [NBP1-87817]

Immunohistochemistry-Paraffin: LKB1/STK11 Antibody [NBP1-87817] - Staining of human colon shows moderate cytoplasmic positivity in glandular cells.
Immunohistochemistry-Paraffin: LKB1/STK11 Antibody [NBP1-87817]

Immunohistochemistry-Paraffin: LKB1/STK11 Antibody [NBP1-87817]

Immunohistochemistry-Paraffin: LKB1/STK11 Antibody [NBP1-87817] - Staining of human testis shows moderate cytoplasmic positivity in cells in seminiferous ducts.
View 1 more images

Applications for LKB1/STK11 Antibody

Application
Recommended Usage

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50
Application Notes
IHC reported in scientific literature (PMID: 25042259). For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: LKB1/STK11

Peutz-Jeghers syndrome (PJS) is a rare hereditary disease characterized by melanocytic macules lips, gastrointestinal hamartomatous polyps and an increased risk for many classes of cancer. LKB1 (also designated STK11 and PJS) has been identified as the gene mutated in PJS. LKB1 is a 433 amino acid Serine/Threonine kinase with strong homology to the Xenopus cytoplasmic protein kinase XEEK1 and weaker similarity to many other protein kinases. LKB1 is ubiquitously expressed and many frameshift, deletion and splicing mutations have been identified in PJS patients. Despite the increased risk of cancer for PJS patients, LKB1 does not appear to play a major role in colorectal, testicular or breast cancers.

Long Name

Serine/threonine Protein Kinase LKB1

Alternate Names

PJS, STK11

Gene Symbol

STK11

Additional LKB1/STK11 Products

Product Documents for LKB1/STK11 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for LKB1/STK11 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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