LRIG1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-30926

Novus Biologicals, part of Bio-Techne
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NBP2-30926
NBP2-30926-25ul
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Key Product Details

Validated by

Knockout/Knockdown

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Knockdown Validated, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all LRIG1 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: TRKKSEEYSVTNTDETVVPPDVPSYLSSQGTLSDRQETVVRTEGGPQANGHIESNGVCPRDASHFPEPDTHSVACRQPKLCAGSAYHKEPWKAMEKAEGTPGPHKMEHGGRVVCSDCNTEVDCYS

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for LRIG1 Antibody

Western Blot: LRIG1 Antibody [NBP2-30926]

Western Blot: LRIG1 Antibody [NBP2-30926]

Western Blot: LRIG1 Antibody [NBP2-30926] - Analysis in U-87MG ATCC cells transfected with control siRNA, target specific siRNA probe #1 and #2,. Remaining relative intensity is presented. Loading control: Anti-GAPDH.
Immunocytochemistry/ Immunofluorescence: LRIG1 Antibody [NBP2-30926]

Immunocytochemistry/ Immunofluorescence: LRIG1 Antibody [NBP2-30926]

Immunocytochemistry/Immunofluorescence: LRIG1 Antibody [NBP2-30926] - Sttaining of human cell line U-251 MG shows localization to cytosol. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: LRIG1 Antibody [NBP2-30926]

Immunohistochemistry-Paraffin: LRIG1 Antibody [NBP2-30926]

Immunohistochemistry-Paraffin: LRIG1 Antibody [NBP2-30926] - Staining of human kidney shows no positivity in cells in tubules as expected.
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Applications for LRIG1 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: LRIG1

LRIG1 (leucine-rich repeat and Ig-like domain-containing-1) is a 145 kDa type I transmembrane glycoprotein that shares 45 - 50% amino acid (aa) identity with two other mammalian LRIG proteins. LRIG1 shows highest expression in subsets of glial cells in brain, and certain epithelia in liver, stomach, small intestine and skeletal muscle. Within the cell, LRIG1 is expressed in the perinuclear region as well as on the surface. LRIG1 binds ErbB receptors and promotes their ubiquitination, internalization and destruction.

Long Name

Leucine-rich Repeats and Immunoglobulin-like Domains 1

Alternate Names

Img, LIG1

Gene Symbol

LRIG1

UniProt

Q96JA1

Additional LRIG1 Products

Product Documents for LRIG1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for LRIG1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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