LRP-6 [p Ser1490] Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-12921

Novus Biologicals, part of Bio-Techne
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NBP3-12921
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Validated:

Human

Predicted:

Mouse (100%), Rhesus Macaque (100%), Xenopus (100%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all LRP-6 Antibodies »

Product Specifications

Immunogen

Carrier-protein conjugated synthetic peptide surrounding phospho Ser1490 of human LRP-6. The exact sequence is proprietary.

Modification

p Ser 1490

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Centrifuge briefly prior to opening.

Scientific Data Images for LRP-6 [p Ser1490] Antibody

Western Blot: LRP-6 [p Ser1490] Antibody [NBP3-12921]

Western Blot: LRP-6 [p Ser1490] Antibody [NBP3-12921]

Western Blot: LRP-6 [p Ser1490] Antibody [NBP3-12921] - Various whole cell extracts (30 ug) were separated by 5% SDS-PAGE, and the membrane was blotted with LRP-6 (phospho Ser1490) antibody (NBP3-12921) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (NBP2-19301) was used to detect the primary antibody.
Western Blot: LRP-6 [p Ser1490] Antibody [NBP3-12921]

Western Blot: LRP-6 [p Ser1490] Antibody [NBP3-12921]

Western Blot: LRP-6 [p Ser1490] Antibody [NBP3-12921] - Untreated (-) and treated (+) HeLa whole cell extracts (30 ug) were separated by 5% SDS-PAGE, and the membrane was blotted with LRP-6 phospho S1490 antibody (NBP3-12921) diluted at 1:1000. (CIP: Calf-intestinal alkaline phosphatase)

Applications for LRP-6 [p Ser1490] Antibody

Application
Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

PBS (pH 7), 20% Glycerol, 1% BSA

Preservative

0.025% Proclin 300

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: LRP-6

Please note, this product is one of a range of Investigative Grade antibodies, made against targets that have limited or no commercial antibodies available to them and for which there are no data on the expression of the protein in the range of common cell lines and tissues available to us. These antibodies are affinity purified using their peptide immunogen and are known to give low background staining in a western blot (see Application Notes below). However no additional claims are made for their ability to recognise native protein in any application. LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.

Long Name

LDL Receptor-related Protein 6

Alternate Names

ADCAD2, FLJ90062, FLJ90421, LRP6

Gene Symbol

LRP6

Additional LRP-6 Products

Product Documents for LRP-6 [p Ser1490] Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for LRP-6 [p Ser1490] Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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