Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all LRRTM3 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 18 amino acid synthetic peptide near the carboxy terminus of human LRRTM3. The immunogen is located within the last 50 amino acids of LRRTM3. Amino Acid Squence: SFETNAQEDTMETHLETE

Specificity

At least two isoforms of LRRTM3 are known to exist; this antibody will only detect the larger isoform.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for LRRTM3 Antibody - BSA Free

Western Blot: LRRTM3 AntibodyBSA Free [NBP1-76529]

Western Blot: LRRTM3 AntibodyBSA Free [NBP1-76529]

Western Blot: LRRTM3 Antibody [NBP1-76529] - Mouse brain tissue lysate with LRRTM3 antibody at 0.5 ug/mL in (A) the absence and (B) the presence of blocking peptide.
LRRTM3 Antibody - BSA Free

Immunohistochemistry: LRRTM3 Antibody - BSA Free [NBP1-76529] -

Immunohistochemistry: LRRTM3 Antibody - BSA Free [NBP1-76529] - Immunohistochemistry of LRRTM3 in human brain tissue with LRRTM3 antibody at 2.5 ug/mL
LRRTM3 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: LRRTM3 Antibody - BSA Free [NBP1-76529] -

Immunocytochemistry/ Immunofluorescence: LRRTM3 Antibody - BSA Free [NBP1-76529] - Immunofluorescence of LRRTM3 in human brain tissue with LRRTM3 antibody at 20 ug/mL.

Applications for LRRTM3 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/ml

Immunohistochemistry

2.5 ug/ml

Immunohistochemistry-Paraffin

2.5 ug/ml

Western Blot

0.5 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: LRRTM3

The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Recent evidence suggests that LRRTM3 promotes the processing of amyloid-precursor protein (APP) by the beta-secretase BACE, leading to the proteolytic production of the Abeta42 peptide that is the main component of amyloid plaques. Furthermore, LRRTM3 maps to a region of chromosome 10 linked to both late-onset Alzheimer's disease (AD) and elevated plasma Abeta42 levels, suggesting that LRRTM3 is a functional and positional candidate gene for AD.

Long Name

Leucine Rich Repeat Transmembrane Neuronal 3

Alternate Names

leucine rich repeat transmembrane neuronal 3, leucine-rich repeat transmembrane neuronal protein 3, MGC131810

Gene Symbol

LRRTM3

UniProt

NP_821079

Additional LRRTM3 Products

Product Documents for LRRTM3 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for LRRTM3 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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