Lyp/PTPN22 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-69989

Novus Biologicals, part of Bio-Techne
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NBP2-69989
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Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

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Product Specifications

Immunogen

Peptide with sequence CPPNKPAESVQSNNS, from the internal region of the protein sequence according to NP_057051; NP_036543.4; NP_001180360.1; NP_001295226.1.

Reactivity Notes

Expected from sequence similarity: Chimpanzee

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Lyp/PTPN22 Antibody

Immunocytochemistry/ Immunofluorescence: Lyp/PTPN22 Antibody [NBP2-69989]

Immunocytochemistry/ Immunofluorescence: Lyp/PTPN22 Antibody [NBP2-69989]

Immunocytochemistry/Immunofluorescence: Lyp/PTPN22 Antibody [NBP2-69989] - Analysis of paraformaldehyde fixed U2OS cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml), showing nuclear staining. Actin filaments were stained with phalloidin (red). Negative control: Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml).
Immunohistochemistry-Paraffin: Lyp/PTPN22 Antibody [NBP2-69989]

Immunohistochemistry-Paraffin: Lyp/PTPN22 Antibody [NBP2-69989]

Immunohistochemistry-Paraffin: Lyp/PTPN22 Antibody [NBP2-69989] - (3.75ug/ml) Human Adrenal Gland. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Flow Cytometry: Lyp/PTPN22 Antibody [NBP2-69989]

Flow Cytometry: Lyp/PTPN22 Antibody [NBP2-69989]

Flow Cytometry: Lyp/PTPN22 Antibody [NBP2-69989] - Analysis of paraformaldehyde fixed Jurkat cells (blue line), permeabilized with 0.5% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (1ug/ml). IgG control: Unimmunized goat IgG (black line) followed by Alexa Fluor 488 secondary antibody.
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Applications for Lyp/PTPN22 Antibody

Application
Recommended Usage

Flow Cytometry

10 ug/ml

Immunocytochemistry/ Immunofluorescence

10 ug/ml

Immunohistochemistry

3.75 ug/ml

Immunohistochemistry-Paraffin

3.75 ug/ml

Peptide ELISA

1:32000

Western Blot

0.5-1ug/ml

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

TBS (pH 7.3), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Lyp

PTPN22 encodes a protein tyrosine phosphatase which is expressed primarily in lymphoid tissues. This enzyme associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.

Long Name

Lymphoid Phosphatase

Alternate Names

LyPTP, PEP, PTPN22, PTPN8 (former)

Gene Symbol

PTPN22

Additional Lyp Products

Product Documents for Lyp/PTPN22 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Lyp/PTPN22 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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