Macro H2A.2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-17197

Novus Biologicals, part of Bio-Techne
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NBP2-17197
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Predicted:

Bovine (100%), Monkey (100%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Macro H2A.2 Antibodies »

Product Specifications

Immunogen

Recombinant protein encompassing a sequence within the center region of human Macro H2A.2. The exact sequence is proprietary.

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Rhesus Monkey (100%).

Localization

Nucleus

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

40 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Macro H2A.2 Antibody

Western Blot: Macro H2A.2 Antibody [NBP2-17197]

Western Blot: Macro H2A.2 Antibody [NBP2-17197]

Western Blot: Macro H2A.2 Antibody [NBP2-17197] - Macro H2A.2 antibody detects Macro H2A.2 protein by Western blot analysis. A. 30 ug 293T whole cell lysate/extract. B. 30 ug whole cell lysate/extract of human H2AFY2-transfected 293T cells. 10 % SDS-PAGE. Macro H2A.2 antibody dilution: 1:1000.
Immunocytochemistry/ Immunofluorescence: Macro H2A.2 Antibody [NBP2-17197]

Immunocytochemistry/ Immunofluorescence: Macro H2A.2 Antibody [NBP2-17197]

Immunocytochemistry/Immunofluorescence: Macro H2A.2 Antibody [NBP2-17197] - Immunofluorescence analysis of paraformaldehyde-fixed A431, using antibody at 1:500 dilution.
Immunohistochemistry-Paraffin: Macro H2A.2 Antibody [NBP2-17197]

Immunohistochemistry-Paraffin: Macro H2A.2 Antibody [NBP2-17197]

Immunohistochemistry-Paraffin: Macro H2A.2 Antibody [NBP2-17197] - Macro H2A.2 antibody detects Macro H2A.2 protein at nucleus in mouse brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse brain. Macro H2A.2 antibody diluted at 1:500.
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Applications for Macro H2A.2 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:100-1:1000

Immunohistochemistry

10 - 1:500

Immunohistochemistry-Paraffin

1:100-1:1000

Western Blot

1:500-1:3000

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

PBS (pH 7), 20% Glycerol, 1% BSA

Preservative

0.01% Thimerosal

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Macro H2A.2

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.

Alternate Names

core histone macro-H2A.2, core histone macroH2A2.2, H2A histone family, member Y2, Histone macroH2A2, macroH2A2, mH2A2

Gene Symbol

MACROH2A2

UniProt

Q9P0M6 (Human)

Additional Macro H2A.2 Products

Product Documents for Macro H2A.2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Macro H2A.2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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